XRN2_ASPFU
ID XRN2_ASPFU Reviewed; 1058 AA.
AC Q8TFZ1; Q4WS77;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=5'-3' exoribonuclease 2;
DE EC=3.1.13.-;
GN Name=rat1; ORFNames=AfA35g10.12, AFUA_1G13730;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=14998527; DOI=10.1016/j.fgb.2003.12.003;
RA Pain A., Woodward J.R., Quail M.A., Anderson M.J., Clark R., Collins M.,
RA Fosker N., Fraser A., Harris D.E., Larke N., Murphy L.D., Humphray S.,
RA O'Neil S., Pertea M., Price C., Rabbinowitsch E., Rajandream M.A.,
RA Salzberg S.L., Saunders D., Seeger K., Sharp S., Warren T., Denning D.W.,
RA Barrell B.G., Hall N.;
RT "Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb
RT region encompassing the nitrate assimilation gene cluster.";
RL Fungal Genet. Biol. 41:443-453(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Required for the
CC processing of nuclear mRNA and rRNA precursors. May promote termination
CC of transcription by RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000305}.
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DR EMBL; BX649607; CAD29606.2; -; Genomic_DNA.
DR EMBL; AAHF01000004; EAL90705.1; -; Genomic_DNA.
DR RefSeq; XP_752743.1; XM_747650.1.
DR AlphaFoldDB; Q8TFZ1; -.
DR SMR; Q8TFZ1; -.
DR STRING; 746128.CADAFUBP00001301; -.
DR EnsemblFungi; EAL90705; EAL90705; AFUA_1G13730.
DR GeneID; 3510193; -.
DR KEGG; afm:AFUA_1G13730; -.
DR VEuPathDB; FungiDB:Afu1g13730; -.
DR eggNOG; KOG2044; Eukaryota.
DR HOGENOM; CLU_006038_1_1_1; -.
DR InParanoid; Q8TFZ1; -.
DR OMA; CLHYYVH; -.
DR OrthoDB; 685597at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004534; F:5'-3' exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0034428; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'; IEA:EnsemblFungi.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:EnsemblFungi.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0106354; P:tRNA surveillance; IEA:EnsemblFungi.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR004859; Put_53exo.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR017151; Xrn2/3/4.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR12341; PTHR12341; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Coiled coil; Exonuclease; Hydrolase; Metal-binding; mRNA processing;
KW Nuclease; Nucleus; Reference proteome; rRNA processing; Transcription;
KW Transcription regulation; Transcription termination; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..1058
FT /note="5'-3' exoribonuclease 2"
FT /id="PRO_0000249918"
FT ZN_FING 268..285
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 418..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 407..443
FT /evidence="ECO:0000255"
FT COMPBIAS 418..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..961
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 119121 MW; 3C4B3A50C2FCB657 CRC64;
MGVPALFRWL SNKYPKIISP VIEELPYEVN GEEIPVDITK PNPNGEEMDN LYLDMNGIVH
PCTHPEGKPP PANEQEMMVE IFKYTDRVVN MVRPRKLLMI AVDGVAPRAK MNQQRARRFR
SAQEAKEADE KKEEFRKMLA KQNGNKVDEE LQEEVVKKTW DSNVITPGTP FMDILAASLR
YWIAYKLNTD PAWEKLKIII SDATVPGEGE HKIMEFIRSQ RAAPEHDPNT RHVIYGLDAD
LIMLGLATHE PHFRVLREDV FFQESRARTC HLCGQQGHKA EECRGQAKEK NGEFDEKQKG
SSLKPFIWLH VSILREYLAA ELYVPHQPFP FDLERALDDW VFMCFFVGND FLPHLPSLDI
RENGIDTLIA IWRDNIPVMG GYLTEDGHVD LKRAQLILQG LAKQEDAIFR RRRQAEERKL
ANEKRRKQEA KAREEERARK RRRSSPTYEP MDSPVGHRAP RGGGDAAPPN QLELITPSRG
ELSRQTRELT HSMVVNRGAV YRANMANKSA AAVLKSKLMQ GSQNGQNGEE KSEGATTNND
EPSQDQPDQT EQTSPSVLGK RKADLVEEED TDAGTPGRDS PAVPVAAKED ELPPDTVRLW
EEGYADRYYE QKFGVDPQDK EFRHKVARAY AEGLAWVLLY YFQGCPSWTW YYPYHYAPFA
ADFVDIGDME ITFDKGVPFK PFEQLMGVLP ASSNHAIPKV FHDLMSSPDS EIIDFYPEDF
AVDLNGKKFA WQGVILLPFI DEKRLLAAME KKYPLLTEDE KLRNSVGREV LLISEAHPLY
QDLVANFYSK KQGVQKYKLN MRISDGLAGK VERNEAYIPH SSLPSSLEEY GMPSLEDDRS
LTVNYEIPKS NHVHKSMLLR GVKFNPPALD NADIQAVKHK AQNSGRSYGG APLRGGQKGG
RINYASDRPN PFAAHLDPGF IPPVPGNVGG GPIMPSGWVP PIPGSAGFSR GPPPPPHGGM
SGSHHRPPYG QGPGQYQGNH GQGDHYGQGQ QGYYNQSSYY NQSNQYNGRS SDHGGSGGYR
GGGGYHRGGN YRGGGYRDQR QYNQDQYSSR NSGGYGRY
