XRN2_GIBZE
ID XRN2_GIBZE Reviewed; 980 AA.
AC Q4HWE2; A0A0E0SQD3; V6S144;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=5'-3' exoribonuclease 2;
DE EC=3.1.13.-;
GN Name=RAT1; ORFNames=FGRRES_10716, FGSG_10716;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Required for the
CC processing of nuclear mRNA and rRNA precursors. May promote termination
CC of transcription by RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000305}.
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DR EMBL; DS231670; ESU18075.1; -; Genomic_DNA.
DR EMBL; HG970334; CEF88646.1; -; Genomic_DNA.
DR RefSeq; XP_011325697.1; XM_011327395.1.
DR AlphaFoldDB; Q4HWE2; -.
DR SMR; Q4HWE2; -.
DR STRING; 5518.FGSG_10716P0; -.
DR EnsemblFungi; ESU18075; ESU18075; FGSG_10716.
DR GeneID; 23557604; -.
DR KEGG; fgr:FGSG_10716; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G20287; -.
DR eggNOG; KOG2044; Eukaryota.
DR HOGENOM; CLU_006038_1_1_1; -.
DR InParanoid; Q4HWE2; -.
DR PHI-base; PHI:1671; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004534; F:5'-3' exoribonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR004859; Put_53exo.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR017151; Xrn2/3/4.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR12341; PTHR12341; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Coiled coil; Exonuclease; Hydrolase; Metal-binding; mRNA processing;
KW Nuclease; Nucleus; Reference proteome; rRNA processing; Transcription;
KW Transcription regulation; Transcription termination; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..980
FT /note="5'-3' exoribonuclease 2"
FT /id="PRO_0000249926"
FT ZN_FING 269..286
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 111..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..145
FT /evidence="ECO:0000255"
FT COILED 411..435
FT /evidence="ECO:0000255"
FT COMPBIAS 413..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..920
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 110362 MW; 53ECA1C9741B45E9 CRC64;
MGIPAAFRWL STRYPKIISP VIEDQPLVME DGSTIPVDTT RPNPNGEEFD NLYLDMNGIV
HPCSHPEDRP APKDEEEMMM EVFRYTDRVV NMVRPRKILM IAVDGVAPRA KMNQQRSRRF
RSAQEAQEKE QDKQELIKML KQQNGGNLST ESLETVTKKA FDSNSITPGT PFMDILALSL
RYWCQYKLNT DPGWAKLKII ISDATVPGEG EHKIMNFVRS QRASPDHDPN TRHVIYGLDA
DLIMLGLATH EPHFRVLRED VFFQDQKARL CKICGQKGHD AQNCRGEEKK KDGEHDEKDK
GVALKPFIWL HVAVLREYLA VELGVPNLPF RFDLERAVDD WIFMCCFVGN DFLPHLPALE
IREHGIDTLT KIWKDNLPVM GGYVTKDGHI DLERAQVILD GLAQQEDNIF KRRKEQEDRR
EANFKRRKLQ NEVNGRGGRQ GGPSHPKKIN GHENPENGLP LQAVGAYTGR HEQTLTHDMV
VNRSTAPDAN VANKSAASVL KAQLQSQKSL SNPKPENPEQ ESPSALGKRK ASSIEEGNSS
VPDAASVSTP STSAEEGPVD DVRLWEDGYA DRYYEKKFHK DPKDIEFRHG VGRAYVEGLA
WVLLYYFQGC PSWEWYYPYH YAPFAADFKD IAKMNISFEK GRVSKPFEQL MSVLPAASRH
ALPEVFHDLM LNPESNIIDF YPEDFEIDLN GKKFAWQGVA LLPFIEMPRL LAAVQSKYPE
LSAADSARNE MGRDVLIFSE GHESLYDEVL TKFYSKKQGD SKFKLNPKKS DGLSGRVEKK
EGYVPHSELK YPLERNSMPD LDYDRSVSVY YDFPQASQTH KSMLLRGVQL PTPALTQNDI
QDMRSRANRG GRGGFGRGHD RGGYNGPGMT RGSQYNRNQG GYGRGNGHYP PAPASHVPPP
PGAPGFGIGV PPPPPPNSYH NQPYDNRYGA SSGYNQYRGP PHPANGAPGY HGHGDASSER
GRGSGGYSSR GRYRDNRSYR
