ID   XRRA1_BOVIN             Reviewed;         549 AA.
AC   Q7PCK7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=X-ray radiation resistance-associated protein 1;
DE   Flags: Fragment;
GN   Name=XRRA1 {ECO:0000312|EMBL:DAA00382.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11282978; DOI=10.1101/gr.170101;
RA   Smith T.P.L., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T.,
RA   Casas E., Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L.,
RA   Heaton M.P., Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G.,
RA   Holt I., Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT   "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT   and construction of a gene index for cattle.";
RL   Genome Res. 11:626-630(2001).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA00382.1}
RP   IDENTIFICATION.
RX   PubMed=12908878; DOI=10.1186/1471-2164-4-32;
RA   Mesak F.M., Osada N., Hashimoto K., Liu Q.Y., Ng C.E.;
RT   "Molecular cloning, genomic characterization and over-expression of a novel
RT   gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR
RT   and macaque testis.";
RL   BMC Genomics 4:32-32(2003).
CC   -!- FUNCTION: May be involved in the response of cells to X-ray radiation.
CC       {ECO:0000250|UniProtKB:Q6P2D8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P2D8}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6P2D8}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA00382.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BE722755; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BI540915; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BM106446; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BM254248; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK000644; DAA00382.1; ALT_INIT; mRNA.
DR   RefSeq; NP_976069.1; NM_203324.1.
DR   AlphaFoldDB; Q7PCK7; -.
DR   SMR; Q7PCK7; -.
DR   STRING; 9913.ENSBTAP00000053271; -.
DR   GeneID; 369019; -.
DR   KEGG; bta:369019; -.
DR   CTD; 143570; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; Q7PCK7; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0010165; P:response to X-ray; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR038894; XRRA1.
DR   PANTHER; PTHR22710; PTHR22710; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome;
KW   Repeat.
FT   CHAIN           <1..549
FT                   /note="X-ray radiation resistance-associated protein 1"
FT                   /id="PRO_0000318129"
FT   REPEAT          37..58
FT                   /note="LRR 1"
FT   REPEAT          62..83
FT                   /note="LRR 2"
FT   REGION          221..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          480..500
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        349..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   549 AA;  62037 MW;  0488037DA8422B11 CRC64;
     LLTGNGLTSL PPSLAVAEQE ASVTSLTTKR YILRFPALET LMLDDNKLSN PNCFVSLAGL
     KRLKKLSLDQ NRIFRIPYLQ QVQLRDGSGD WVGGRGSPRK QPQSMLQSKS WIYEASDDQP
     DYTILPMKKD VDRTEVVFSS YPGFSTSETT KVCALPPIFA ILPVALFPSL CELIFHNNPL
     VAHTRGVPPL LKSFLQERVG IHLIRRKIVK AKHHILMPRK DSRKVKTQVP KVPKQPMILP
     HPSVMIKSPS KEMLESEAEL TTEPPPTKTI SVEREMPIEG LGGPPMPHRT FVPLPPICSD
     STVHSEETSP RSDAAGRLSA DQLSDEDTKS TESIFLTQVS GLSSSIFQRD DSEIKEKEQR
     PPSTAPREAK RTQKKPPSAS FPRKYHGYEE LLTAKPDRPC STCVKHPLVY RSSKPRLDTL
     QKHYVPKEKR TRRIPVPPRR KTRAQLLDDI LIRMRDTQNI TEAPLGAVLR QRTEQRLVNQ
     KQFLEAKKLL KEFRARYRRL VRCSLRSVFG TTAPPQARPA LSGSQPKLGR FLEFMDEFYQ
     EPTASDLKG