ID   XRRA1_MACFA             Reviewed;         587 AA.
AC   Q95LL2; Q95JZ0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=X-ray radiation resistance-associated protein 1;
DE   Flags: Fragment;
GN   Name=XRRA1 {ECO:0000312|EMBL:BAB69745.1}; ORFNames=QtsA-12093, QtsA-20433;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAB69745.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:BAB69745.1};
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=12908878; DOI=10.1186/1471-2164-4-32;
RA   Mesak F.M., Osada N., Hashimoto K., Liu Q.Y., Ng C.E.;
RT   "Molecular cloning, genomic characterization and over-expression of a novel
RT   gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR
RT   and macaque testis.";
RL   BMC Genomics 4:32-32(2003).
CC   -!- FUNCTION: May be involved in the response of cells to X-ray radiation.
CC       {ECO:0000250|UniProtKB:Q6P2D8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P2D8}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6P2D8}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in testis.
CC       {ECO:0000269|PubMed:12908878}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB62982.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB69745.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB070037; BAB62982.1; ALT_INIT; mRNA.
DR   EMBL; AB072776; BAB69745.1; ALT_INIT; mRNA.
DR   RefSeq; XP_015290982.1; XM_015435496.1.
DR   AlphaFoldDB; Q95LL2; -.
DR   STRING; 9541.XP_005579140.1; -.
DR   PRIDE; Q95LL2; -.
DR   GeneID; 102115025; -.
DR   CTD; 143570; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0010165; P:response to X-ray; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR038894; XRRA1.
DR   PANTHER; PTHR22710; PTHR22710; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome;
KW   Repeat.
FT   CHAIN           <1..587
FT                   /note="X-ray radiation resistance-associated protein 1"
FT                   /id="PRO_0000318131"
FT   REPEAT          24..45
FT                   /note="LRR 1"
FT   REPEAT          49..70
FT                   /note="LRR 2"
FT   REGION          337..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          518..540
FT                   /evidence="ECO:0000255"
FT   CONFLICT        389
FT                   /note="T -> I (in Ref. 1; BAB62982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        434
FT                   /note="N -> D (in Ref. 1; BAB62982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        537
FT                   /note="Q -> R (in Ref. 1; BAB62982)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   587 AA;  66521 MW;  84C2F286E1270FF3 CRC64;
     LAVAEQEASV TSLTSKRYIL RFPALETLML DDNRLSNPSC FASLAGLRRL KKLSLDENRI
     IRIPYLQQVQ LSDESVDWNG GGGSPQKEPQ FMLQSKPRML EDSDEQLDYT VLPMKKDVDR
     TEVVFSSYPG FSTSETTKIC SLPPIFEILP VKSLKARNQT LAPPFPELRY LSLAYNKIAK
     EDAVLPVALF PSLCEFVFHN NPLVAHTRGV PPLLKSFLQE RLGIHLIRRK TVKPKHHVLM
     SRKESRKVKT EIPKVPKQPL VLHHPQVTTN KSPSKDMLEP EAELAEDLPT TKSTFVESEM
     PTESLEGLSL SRRTFVPLPP ICSDSTVHSE ETLSHLSDTA VRLSPEHPSD EDSKSTESIF
     LTQVSELPSS IIHKDDLELK EKDQKKPPTA PREVKVTRRK LTTASLPSKY HGYEELLTAK
     PDPAFIEPKG IQKNAQALQH MLKHPLLCHS SKPKLDTLQK PYVPKEKRAQ RIPIPPPRKT
     RTQLLDDIFI RLRDPRNITE APLGAVLHRR TERRLVNHKQ YLEAKRLLKE FQARYRQLVS
     GSLRTVFGTT PLPPACPALS ESQPKFGRFL EFMDEFCQEP TASDSQG