XRRA1_MOUSE
ID XRRA1_MOUSE Reviewed; 786 AA.
AC Q3U3V8; B2RX67; Q7M740;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=X-ray radiation resistance-associated protein 1;
GN Name=Xrra1 {ECO:0000312|MGI:MGI:2181647};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE32677.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD {ECO:0000312|EMBL:BAE32677.1};
RC TISSUE=Dendritic cell {ECO:0000312|EMBL:BAE32677.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA00368.1}
RP IDENTIFICATION.
RX PubMed=12908878; DOI=10.1186/1471-2164-4-32;
RA Mesak F.M., Osada N., Hashimoto K., Liu Q.Y., Ng C.E.;
RT "Molecular cloning, genomic characterization and over-expression of a novel
RT gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR
RT and macaque testis.";
RL BMC Genomics 4:32-32(2003).
CC -!- FUNCTION: May be involved in the response of cells to X-ray radiation.
CC {ECO:0000250|UniProtKB:Q6P2D8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P2D8}. Nucleus
CC {ECO:0000250|UniProtKB:Q6P2D8}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA00368.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK154558; BAE32677.1; -; mRNA.
DR EMBL; BC151014; AAI51015.1; -; mRNA.
DR EMBL; BC151020; AAI51021.1; -; mRNA.
DR EMBL; BK000542; DAA00368.1; ALT_INIT; mRNA.
DR CCDS; CCDS52321.1; -.
DR RefSeq; NP_001157730.1; NM_001164258.1.
DR RefSeq; XP_006508070.1; XM_006508007.2.
DR AlphaFoldDB; Q3U3V8; -.
DR STRING; 10090.ENSMUSP00000035929; -.
DR iPTMnet; Q3U3V8; -.
DR PhosphoSitePlus; Q3U3V8; -.
DR PaxDb; Q3U3V8; -.
DR PRIDE; Q3U3V8; -.
DR ProteomicsDB; 300015; -.
DR Antibodypedia; 45035; 54 antibodies from 15 providers.
DR Ensembl; ENSMUST00000036155; ENSMUSP00000035929; ENSMUSG00000035211.
DR GeneID; 446101; -.
DR KEGG; mmu:446101; -.
DR UCSC; uc009ime.2; mouse.
DR CTD; 143570; -.
DR MGI; MGI:2181647; Xrra1.
DR VEuPathDB; HostDB:ENSMUSG00000035211; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00390000016048; -.
DR HOGENOM; CLU_015169_0_0_1; -.
DR InParanoid; Q3U3V8; -.
DR OMA; CELVFHN; -.
DR OrthoDB; 799626at2759; -.
DR PhylomeDB; Q3U3V8; -.
DR TreeFam; TF329758; -.
DR BioGRID-ORCS; 446101; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Xrra1; mouse.
DR PRO; PR:Q3U3V8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3U3V8; protein.
DR Bgee; ENSMUSG00000035211; Expressed in spermatid and 43 other tissues.
DR ExpressionAtlas; Q3U3V8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0010165; P:response to X-ray; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR038894; XRRA1.
DR PANTHER; PTHR22710; PTHR22710; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..786
FT /note="X-ray radiation resistance-associated protein 1"
FT /id="PRO_0000318132"
FT REPEAT 146..158
FT /note="LRR 1"
FT REPEAT 169..192
FT /note="LRR 2"
FT REPEAT 193..214
FT /note="LRR 3"
FT REPEAT 234..255
FT /note="LRR 4"
FT REPEAT 259..280
FT /note="LRR 5"
FT REGION 474..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 714..738
FT /evidence="ECO:0000255"
FT COMPBIAS 525..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 88884 MW; A5D3C640F1243F44 CRC64;
MVSSGMYKMD NGKPCLNNCF PAKSLLRLPE EGRGHWIVVR KGSMKKGAAK ASTEGQESQK
KVSFDTGLKK ISRRDSQADV LGHILDRSFL LKHHSARKPS DLCTINVSGM KFSKAKEKDF
KHFTSVIYIN ASENLLPLDV FHTFPVLKEL ELAFNGIKMV YVKYGDFKTL EFLDLSFNSL
TEEAICDLGI LPHLRVLLLT GNGLTSLPPN MAVKEQEASM TSLTSKKYIL RFPALETLML
DDNKLSNPSC FASLAGLRRL KKLSLDQNKI VRIPYLQQIQ LRDGSGDWVT EGPNPQKELQ
PQMWIFETPD EQPNYTVLPM KKDVDRTEVV FSSYPGFSTS ETAKVCSLPP MFEILPVKSL
KARNQTLAPP FPELRYLSLA YNKIAKEDAV LPAALFPSLC ELVFHNNPLV AHTRGIPPLL
KSFLQDRLGI RLVRKKLVKP KHHMLMPRKE SRKVKTYIPK VPKHSLVPHH LNMITDSPPS
SLMPEPEHST EDTSHEALFA NEGPEGPSLT HRAFVPMPPI CSDSTVHSEA VSHQSHTAGL
VSSEHPSDDD AKSTESIFLT QVNELPSSTA HRENLEAVND QRRPSTAPRE TKRTRRKQTA
TSLHNKYDGY EELLTVKPDP AFLEPKGIQK NAQALHRMLK QPLICRSSKP RLDTFQKPYV
PKEKRAGRIP ILPPRKTRAQ LLDDILIRMR DPRNVTEAPL GTVLQRRAQQ RLVNQKQYRE
AKRLLKEFRA RYRQLVRSSL RTVFAASPPP RPPTRRALSA GQPKLGRFLE FMDEFCQEPT
ASDSKE
