XT2_XENTR
ID XT2_XENTR Reviewed; 25 AA.
AC P84382;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Antimicrobial peptide 2;
DE AltName: Full=XT-2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:11738090};
RX PubMed=11738090; DOI=10.1016/s0167-4838(01)00272-2;
RA Ali M.F., Soto A., Knoop F.C., Conlon J.M.;
RT "Antimicrobial peptides isolated from skin secretions of the diploid frog,
RT Xenopus tropicalis (Pipidae).";
RL Biochim. Biophys. Acta 1550:81-89(2001).
CC -!- FUNCTION: Has very strong antibacterial activity against Gram-positive
CC bacterium S.aureus and very weak activity against Gram-negative
CC bacterium E.coli. {ECO:0000269|PubMed:11738090}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11738090}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:11738090}.
CC -!- MASS SPECTROMETRY: Mass=2569.9; Mass_error=0.5; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:11738090};
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DR AlphaFoldDB; P84382; -.
DR Proteomes; UP000008143; Genome assembly.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0044179; P:hemolysis in another organism; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Reference proteome; Secreted.
FT PEPTIDE 1..25
FT /note="Antimicrobial peptide 2"
FT /id="PRO_0000043866"
SQ SEQUENCE 25 AA; 2570 MW; A04663F00F948C7A CRC64;
GVWSTVLGGL KKFAKGGLEA IVNPK