CAPA_AGRIP
ID CAPA_AGRIP Reviewed; 157 AA.
AC C0HKS6; C0HKS7; C0HKS8; C0HKS9; C0HKT0;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=CAPA peptides {ECO:0000305};
DE Contains:
DE RecName: Full=CAPA-periviscerokinin 1 {ECO:0000305|PubMed:29466015};
DE Short=CAPA-PVK-1 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=CAPA-periviscerokinin 2 {ECO:0000305|PubMed:29466015};
DE Short=CAPA-PVK-2 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=CAPA-periviscerokinin 3 {ECO:0000305|PubMed:29466015};
DE Short=CAPA-PVK-3 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=CAPA-trypto-pyrokinin {ECO:0000305|PubMed:29466015};
DE AltName: Full=CAPA-tryptoPK {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=CAPA-precursor-related peptide 3 {ECO:0000305|PubMed:29466015};
DE Short=CAPA-PP-3 {ECO:0000303|PubMed:29466015};
DE Flags: Precursor;
OS Agrotis ipsilon (Black cutworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Noctuinae; Noctuini; Agrotis.
OX NCBI_TaxID=56364;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-42; 69-76; 79-85; 88-103
RP AND 106-117, TISSUE SPECIFICITY, MASS SPECTROMETRY, IDENTIFICATION BY MASS
RP SPECTROMETRY, AMIDATION AT VAL-42; VAL-76; LEU-85 AND LEU-117, AND
RP PYROGLUTAMATE FORMATION AT GLN-69.
RX PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA Schachtner J., Jacquin-Joly E., Gadenne C.;
RT "Mating-induced differential peptidomics of neuropeptides and protein
RT hormones in Agrotis ipsilon moths.";
RL J. Proteome Res. 17:1397-1414(2018).
CC -!- FUNCTION: [CAPA-trypto-pyrokinin]: Myoactive.
CC {ECO:0000250|UniProtKB:P82693}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: CAPA-periviscerokinin 1: Expressed in corpora
CC cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal
CC ganglion (GNG) (at protein level). Expression detected in most animals
CC in CC and CA and in some animals in AL and GNG (at protein level).
CC CAPA-periviscerokinin 2: Expressed in corpora cardiaca (CC), corpora
CC allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein
CC level). For non-pyroglutamate form, expression in AL detected in all
CC animals, in CC, CA and GNG in most animals (at protein level). For
CC pyroglutamate form, expression in CC and CA detected in most animals,
CC in AL and GNG in some animals (at protein level). CAPA-periviscerokinin
CC 3: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal
CC lobe (AL) and gnathal ganglion (GNG). Expression detected in most
CC animals in CC and CA and in some animals in AL and GNG (at protein
CC level). CAPA-precursor-related peptide 3: Expressed in corpora cardiaca
CC (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion
CC (GNG) (at protein level). Expression in CC and CA detected in some
CC animals, expression in Al and GNG detected in few animals (at protein
CC level). CAPA-trypto-pyrokinin: Expressed in corpora cardiaca (CC),
CC corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at
CC protein level). Expression in CC, CA and GNG detected in most animals,
CC in AL in some animals (at protein level).
CC {ECO:0000269|PubMed:29466015}.
CC -!- MASS SPECTROMETRY: [CAPA-periviscerokinin 1]: Mass=1420.78;
CC Mass_error=0.01; Method=MALDI; Note=Periviscerokinin 1.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [CAPA-periviscerokinin 2]: Mass=992.55;
CC Mass_error=0.01; Method=MALDI; Note=Periviscerokinin 2.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [CAPA-periviscerokinin 2]: Mass=975.51;
CC Mass_error=0.01; Method=MALDI; Note=Pyroglutamate-modified
CC periviscerokinin 2.; Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [CAPA-periviscerokinin 3]: Mass=816.47;
CC Mass_error=0.01; Method=MALDI; Note=Periviscerokinin 3.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [CAPA-precursor-related peptide 3]: Mass=1831.87;
CC Mass_error=0.01; Method=MALDI; Note=CAPA-PP 3.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [CAPA-trypto-pyrokinin]: Mass=1376.70;
CC Mass_error=0.01; Method=MALDI; Note=Pyrokinin.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
CC -!- CAUTION: Further mature peptides might exist. {ECO:0000305}.
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DR AlphaFoldDB; C0HKS6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR001484; Pyrokinin_CS.
DR PROSITE; PS00539; PYROKININ; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..28
FT /evidence="ECO:0000305"
FT /id="PRO_0000444214"
FT PEPTIDE 31..42
FT /note="CAPA-periviscerokinin 1"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444215"
FT PROPEP 45..66
FT /evidence="ECO:0000305"
FT /id="PRO_0000444216"
FT PEPTIDE 69..76
FT /note="CAPA-periviscerokinin 2"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444217"
FT PEPTIDE 79..85
FT /note="CAPA-periviscerokinin 3"
FT /evidence="ECO:0000303|PubMed:29466015"
FT /id="PRO_0000444218"
FT PEPTIDE 88..103
FT /note="CAPA-precursor-related peptide 3"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444219"
FT PEPTIDE 106..117
FT /note="CAPA-trypto-pyrokinin"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444220"
FT PROPEP 120..157
FT /evidence="ECO:0000305"
FT /id="PRO_0000444221"
FT REGION 131..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 69
FT /note="Pyrrolidone carboxylic acid; partial"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 76
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 85
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 117
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
SQ SEQUENCE 157 AA; 18230 MW; 0F2CAB8391A39F46 CRC64;
MQPTMRIIVS MALLAYAVAS AYHSNVKLRR DGKMVLYPFP RVGRASGNTW QLPLNDLYPE
YEPAQVKRQL YAFPRVGRDP VMSRLGRSDL SRVESHEFQP MAVRRTESPG MWFGPRLGRA
FKNDDDEITI QNESNDHSEP EQTELIHEDR RKRQTLN
