ID   CAPA_STAAN              Reviewed;         220 AA.
AC   P63859; Q99QX4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CapA;
GN   Name=capA; OrderedLocusNames=SA2457;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide. {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43762.1; -; Genomic_DNA.
DR   PIR; H90074; H90074.
DR   RefSeq; WP_000659683.1; NC_002745.2.
DR   AlphaFoldDB; P63859; -.
DR   SMR; P63859; -.
DR   EnsemblBacteria; BAB43762; BAB43762; BAB43762.
DR   KEGG; sau:SA2457; -.
DR   HOGENOM; CLU_082668_1_1_9; -.
DR   OMA; KICEVFV; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..220
FT                   /note="Capsular polysaccharide biosynthesis protein CapA"
FT                   /id="PRO_0000217219"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24398 MW;  C667613BB086FE54 CRC64;
     MKEKFDLVKL LNILKKNIKL LLILPAICLV VSTALTFFVM PDKYTASTQI LVNMKKSSSD
     LAFQNVQSSL QSVNTYTEII KSPRILDKVS REFDGQYSTA ELNSFLKVTN QTNSQIITVS
     VTTGNKSESD KIVNRISKVF AHDMPKIMSV DNVTILSSAH DNAVKVSPIV SVNLVISIIV
     GIVLAILIIF LKELLDKRIK TEEDVESQLG LPILGSIQKF