ID   CAPA_STAAR              Reviewed;         220 AA.
AC   Q6GDE0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CapA;
GN   Name=capA; OrderedLocusNames=SAR2745;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide. {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41721.1; -; Genomic_DNA.
DR   RefSeq; WP_000659677.1; NC_002952.2.
DR   AlphaFoldDB; Q6GDE0; -.
DR   SMR; Q6GDE0; -.
DR   KEGG; sar:SAR2745; -.
DR   HOGENOM; CLU_082668_1_1_9; -.
DR   OMA; KICEVFV; -.
DR   OrthoDB; 1184929at2; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..220
FT                   /note="Capsular polysaccharide biosynthesis protein CapA"
FT                   /id="PRO_0000217220"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24368 MW;  9B177D42D58F922D CRC64;
     MKEKFDLVKL LNILKKNIKL LLILPAICLV VSAALTFFVM PDKYTASTQI LVNMKKSSSD
     LAFQNVQSSL QSVNTYTEII KSPRILDKVS REFDGQYSTA ELNSFLKVTN QTNSQIITVS
     VTTGNKSESD KIVNRISKVF AHDMPKIMSV DNVTILSSAH DNAVKVSPIV SVNLVISIIV
     GIVLAILIIF LKELLDKRIK TEEDVESQLG LPILGSIQKF