ID   CAPA_STAAW              Reviewed;         220 AA.
AC   Q9RQQ1;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CapA;
GN   Name=capA; OrderedLocusNames=MW2584;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide. {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB96449.1; -; Genomic_DNA.
DR   RefSeq; WP_000659675.1; NC_003923.1.
DR   AlphaFoldDB; Q9RQQ1; -.
DR   SMR; Q9RQQ1; -.
DR   EnsemblBacteria; BAB96449; BAB96449; BAB96449.
DR   KEGG; sam:MW2584; -.
DR   HOGENOM; CLU_082668_1_1_9; -.
DR   OMA; KICEVFV; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..220
FT                   /note="Capsular polysaccharide biosynthesis protein CapA"
FT                   /id="PRO_0000217223"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24340 MW;  1A9E65CBD59D376A CRC64;
     MKEKFDLVKL LNILKKNIKL LLILPAICLV VSAALTFFVM PDKYTASTQI LVNMKKSSSD
     LAFQNVQSSL QSVNTYTEII KSPRILDKVS REFDGQYSTA ELNSFLKVTN QTNSQIITVS
     VTTGNKSESD KIVNKISKVF AHDMPKIMSV DNVTILSSAH DNAVKVSPIV SVNLVISIIV
     GIVLAILIIF LKELLDKRIK TEEDVESQLG LPILGSIQKF