XYLB_BOVIN
ID XYLB_BOVIN Reviewed; 490 AA.
AC Q3SYZ6;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Xylulose kinase;
DE Short=Xylulokinase;
DE EC=2.7.1.17;
GN Name=XYLB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate,
CC a molecule that may play an important role in the regulation of glucose
CC metabolism and lipogenesis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+);
CC Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC EC=2.7.1.17;
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR EMBL; BC103316; AAI03317.1; -; mRNA.
DR RefSeq; NP_001029655.1; NM_001034483.1.
DR AlphaFoldDB; Q3SYZ6; -.
DR SMR; Q3SYZ6; -.
DR STRING; 9913.ENSBTAP00000030820; -.
DR PaxDb; Q3SYZ6; -.
DR PeptideAtlas; Q3SYZ6; -.
DR Ensembl; ENSBTAT00000030851; ENSBTAP00000030820; ENSBTAG00000011278.
DR GeneID; 515146; -.
DR KEGG; bta:515146; -.
DR CTD; 9942; -.
DR VEuPathDB; HostDB:ENSBTAG00000011278; -.
DR VGNC; VGNC:37011; XYLB.
DR eggNOG; KOG2531; Eukaryota.
DR GeneTree; ENSGT01000000214434; -.
DR HOGENOM; CLU_016149_8_0_1; -.
DR InParanoid; Q3SYZ6; -.
DR OrthoDB; 592116at2759; -.
DR TreeFam; TF313643; -.
DR BioCyc; MetaCyc:MON-13243; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000011278; Expressed in liver and 103 other tissues.
DR ExpressionAtlas; Q3SYZ6; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR GO; GO:0004856; F:xylulokinase activity; ISS:UniProtKB.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0005997; P:xylulose metabolic process; ISS:UniProtKB.
DR CDD; cd07776; FGGY_D-XK_euk; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR042024; D-XK_euk.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase; Xylose metabolism.
FT CHAIN 1..490
FT /note="Xylulose kinase"
FT /id="PRO_0000230984"
FT BINDING 99
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 170
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 280
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 281
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 355
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 441..442
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 445
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 490 AA; 53305 MW; C681FED9E37A01F3 CRC64;
MAERAARHCC LGWDFSTQQV KVVAVDAELS VFYEDSVHFD RDLVEFGTQG GVHVHKDGLT
VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SVYWKTGASQ VLTSLSPDLP
LREQLQACFS ISNCPVWMDS STAAQCRQLE AAVGGAQALS LLTGSRAYER FTGNQIAKIY
QQNPEAYSHT ERISLVSSFA ASLFLGSYSP VDYSDGSGMN LLQIQDKVWS QACLGACAPR
LEEKLGRPVP SCSIVGAISS YFVQRYGFPP ECKVVAFTGD NPASLAGMRL EEGDIAVSLG
TSDTLFLWLQ EPTPALEGHI FCNPVDPQHY MALLCFKNGS LMREKIRDES ASGSWSKFSK
ALQSTGMGNS GNLGFYFDVM EITPEIIGRH RFTAENHEVS AFPQDVEIRA LIEGQFMAKK
IHAEALGYRV MPKTKILATG GASHNRDILQ VLADVFGAPV YVIDTANSAC VGSAYRAFHG
PSLLCLVSIY