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XYLB_BOVIN
ID   XYLB_BOVIN              Reviewed;         490 AA.
AC   Q3SYZ6;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Xylulose kinase;
DE            Short=Xylulokinase;
DE            EC=2.7.1.17;
GN   Name=XYLB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate,
CC       a molecule that may play an important role in the regulation of glucose
CC       metabolism and lipogenesis. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+);
CC         Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC         EC=2.7.1.17;
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR   EMBL; BC103316; AAI03317.1; -; mRNA.
DR   RefSeq; NP_001029655.1; NM_001034483.1.
DR   AlphaFoldDB; Q3SYZ6; -.
DR   SMR; Q3SYZ6; -.
DR   STRING; 9913.ENSBTAP00000030820; -.
DR   PaxDb; Q3SYZ6; -.
DR   PeptideAtlas; Q3SYZ6; -.
DR   Ensembl; ENSBTAT00000030851; ENSBTAP00000030820; ENSBTAG00000011278.
DR   GeneID; 515146; -.
DR   KEGG; bta:515146; -.
DR   CTD; 9942; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011278; -.
DR   VGNC; VGNC:37011; XYLB.
DR   eggNOG; KOG2531; Eukaryota.
DR   GeneTree; ENSGT01000000214434; -.
DR   HOGENOM; CLU_016149_8_0_1; -.
DR   InParanoid; Q3SYZ6; -.
DR   OrthoDB; 592116at2759; -.
DR   TreeFam; TF313643; -.
DR   BioCyc; MetaCyc:MON-13243; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000011278; Expressed in liver and 103 other tissues.
DR   ExpressionAtlas; Q3SYZ6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR   GO; GO:0004856; F:xylulokinase activity; ISS:UniProtKB.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR   GO; GO:0005997; P:xylulose metabolic process; ISS:UniProtKB.
DR   CDD; cd07776; FGGY_D-XK_euk; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR042024; D-XK_euk.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase; Xylose metabolism.
FT   CHAIN           1..490
FT                   /note="Xylulose kinase"
FT                   /id="PRO_0000230984"
FT   BINDING         99
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         170
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         280
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         281
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         355
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         441..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         445
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   490 AA;  53305 MW;  C681FED9E37A01F3 CRC64;
     MAERAARHCC LGWDFSTQQV KVVAVDAELS VFYEDSVHFD RDLVEFGTQG GVHVHKDGLT
     VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SVYWKTGASQ VLTSLSPDLP
     LREQLQACFS ISNCPVWMDS STAAQCRQLE AAVGGAQALS LLTGSRAYER FTGNQIAKIY
     QQNPEAYSHT ERISLVSSFA ASLFLGSYSP VDYSDGSGMN LLQIQDKVWS QACLGACAPR
     LEEKLGRPVP SCSIVGAISS YFVQRYGFPP ECKVVAFTGD NPASLAGMRL EEGDIAVSLG
     TSDTLFLWLQ EPTPALEGHI FCNPVDPQHY MALLCFKNGS LMREKIRDES ASGSWSKFSK
     ALQSTGMGNS GNLGFYFDVM EITPEIIGRH RFTAENHEVS AFPQDVEIRA LIEGQFMAKK
     IHAEALGYRV MPKTKILATG GASHNRDILQ VLADVFGAPV YVIDTANSAC VGSAYRAFHG
     PSLLCLVSIY
 
 
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