XYLB_HAEIN
ID XYLB_HAEIN Reviewed; 493 AA.
AC P44401;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Xylulose kinase {ECO:0000255|HAMAP-Rule:MF_02220};
DE Short=Xylulokinase {ECO:0000255|HAMAP-Rule:MF_02220};
DE EC=2.7.1.17 {ECO:0000255|HAMAP-Rule:MF_02220};
GN Name=xylB {ECO:0000255|HAMAP-Rule:MF_02220}; OrderedLocusNames=HI_1113;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-
CC phosphate. {ECO:0000255|HAMAP-Rule:MF_02220}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+);
CC Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC EC=2.7.1.17; Evidence={ECO:0000255|HAMAP-Rule:MF_02220};
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000255|HAMAP-
CC Rule:MF_02220, ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC22767.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC22767.1; ALT_INIT; Genomic_DNA.
DR PIR; E64183; E64183.
DR RefSeq; NP_439270.1; NC_000907.1.
DR RefSeq; WP_032828343.1; NC_000907.1.
DR AlphaFoldDB; P44401; -.
DR SMR; P44401; -.
DR STRING; 71421.HI_1113; -.
DR EnsemblBacteria; AAC22767; AAC22767; HI_1113.
DR KEGG; hin:HI_1113; -.
DR PATRIC; fig|71421.8.peg.1162; -.
DR eggNOG; COG1070; Bacteria.
DR HOGENOM; CLU_009281_3_0_6; -.
DR PhylomeDB; P44401; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004856; F:xylulokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0005998; P:xylulose catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_02220; XylB; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR006000; Xylulokinase.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR01312; XylB; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Carbohydrate metabolism; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase; Xylose metabolism.
FT CHAIN 1..493
FT /note="Xylulose kinase"
FT /id="PRO_0000059550"
FT ACT_SITE 247
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
FT BINDING 84..85
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
FT SITE 6
FT /note="Important for activity"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02220"
SQ SEQUENCE 493 AA; 54804 MW; 0F7C72AEB26FEDD6 CRC64;
MYIGIDCGTQ GTKAIVLDSV QKKVIGVGYA KHELITQSNG RREQQPNWWI EALQQALQIA
LKQAKNSPHF SPNLVKGIGI SGQQHGLVML DKNDRPLYKA KLWCDTETAT ENDILIEKLG
GQTAVFEKLG IICQTGYTAS KLSWFRQNYP DKFANIRKIM LPHDYLNYWL TGKFCTEFGD
ASGSGYFDVV KREWKREVFK YLAPELNMDE VLPKLLSAEQ KIGVIKPEIA TLFGFNENVI
VSTGGGDNMM GAIGTGNIRE GIATMSLGTS GTLYAYTQKP LLNLPPMIAN FCSSNNGWLP
LVCVMNITSS NKQLMNLLNI DIEELNQLAQ QAPIGANGIT ILPFFNGERV PPLPNTKASI
LGLDSSNFTR ENLCRAMMES ATFTLRYGLD LFRQAGLKTS QIRLIGGGAK SSFWRQMIAD
VMNSEVVCLQ EEEAAALGGA IQAMWANGEG ELEFLCETFI HLDENSKAYP NLSQVKNYQN
AYERYLTHLS QLY
