ID   CAPC_BACAN              Reviewed;         149 AA.
AC   P19581;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Capsule biosynthesis protein CapC;
GN   Name=capC; OrderedLocusNames=pXO2-57, BXB0065, GBAA_pXO2_0065;
OS   Bacillus anthracis.
OG   Plasmid pXO2, and Plasmid pTE702.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pTE702;
RX   PubMed=2536679; DOI=10.1128/jb.171.2.722-730.1989;
RA   Makino S., Uchida I., Terakado N., Sasakawa C., Yoshikawa M.;
RT   "Molecular characterization and protein analysis of the cap region, which
RT   is essential for encapsulation in Bacillus anthracis.";
RL   J. Bacteriol. 171:722-730(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Pasteur; PLASMID=pXO2;
RX   PubMed=10475962; DOI=10.1046/j.1365-2672.1999.00883.x;
RA   Okinaka R.T., Cloud K., Hampton O., Hoffmaster A., Hill K.K., Keim P.,
RA   Koehler T., Lamke G., Kumano S., Manter D., Martinez Y., Ricke D.,
RA   Svensson R., Jackson P.J.;
RT   "Sequence, assembly and analysis of pXO1 and pXO2.";
RL   J. Appl. Microbiol. 87:261-262(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ames / isolate Florida / A2012; PLASMID=pXO2;
RX   PubMed=12004073; DOI=10.1126/science.1071837;
RA   Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L.,
RA   Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P.,
RA   Fraser C.M.;
RT   "Comparative genome sequencing for discovery of novel polymorphisms in
RT   Bacillus anthracis.";
RL   Science 296:2028-2033(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor; PLASMID=pXO2;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [5]
RP   INDUCTION.
RC   PLASMID=pXO2;
RX   PubMed=14702298; DOI=10.1128/jb.186.2.307-315.2004;
RA   Drysdale M., Bourgogne A., Hilsenbeck S.G., Koehler T.M.;
RT   "atxA controls Bacillus anthracis capsule synthesis via acpA and a newly
RT   discovered regulator, acpB.";
RL   J. Bacteriol. 186:307-315(2004).
CC   -!- FUNCTION: Essential for the synthesis of the polyglutamate capsule of
CC       B.anthracis which is one of the principal virulence factors during
CC       anthrax infection. May form a polyglutamyl synthetase complex together
CC       with proteins CapA and CapB. CapC may be the endogenous acceptor of
CC       glutamyl residues.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Capsule synthesis is transcriptionally regulated by AtxA,
CC       AcpA and AcpB. {ECO:0000269|PubMed:14702298}.
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DR   EMBL; M24150; AAA22287.1; -; Genomic_DNA.
DR   EMBL; AF188935; AAF13662.1; -; Genomic_DNA.
DR   EMBL; AE011191; AAM26221.1; -; Genomic_DNA.
DR   EMBL; AE017335; AAT28995.2; -; Genomic_DNA.
DR   PIR; B30091; B30091.
DR   RefSeq; NP_053212.1; NC_002146.1.
DR   RefSeq; WP_000468007.1; NZ_VTZL01000009.1.
DR   AlphaFoldDB; P19581; -.
DR   EnsemblBacteria; AAT28995; AAT28995; GBAA_pXO2_0065.
DR   GeneID; 45025366; -.
DR   KEGG; bar:GBAA_pXO2_0065; -.
DR   HOGENOM; CLU_143404_1_0_9; -.
DR   OMA; CITYVIL; -.
DR   BioCyc; MetaCyc:MON-16981; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000594; Plasmid pXO2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR008338; Capsule_biosynth_CapC.
DR   Pfam; PF14102; Caps_synth_CapC; 1.
DR   PRINTS; PR01759; CAPSULEPROTC.
DR   TIGRFAMs; TIGR04011; poly_gGlu_PgsC; 1.
PE   2: Evidence at transcript level;
KW   Capsule biogenesis/degradation; Cell membrane; Membrane; Plasmid;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..149
FT                   /note="Capsule biosynthesis protein CapC"
FT                   /id="PRO_0000089310"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   149 AA;  16523 MW;  A93D4F792FA5E940 CRC64;
     MFGSDLYIAL VLGVTLSLIF TERTGILPAG LVVPGYLALV FNQPVFMLVV LFISILTYVI
     VTYGVSRFMI LYGRRKFAAT LITGICLKLL FDYCYPVMPF EIFEFRGIGV IVPGLIANTI
     QRQGLPLTIG TTILLSGATF AIMNIYYLF