CAPC_BACSU
ID CAPC_BACSU Reviewed; 149 AA.
AC P96737; Q795C7; Q9AJM2;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=PGA biosynthesis protein CapC;
GN Name=capC; Synonyms=pgsC, ywtA; OrderedLocusNames=BSU35890;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA Kunst F., Danchin A., Glaser P.;
RT "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT degrees).";
RL Microbiology 143:3313-3328(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NBRC 3336;
RX PubMed=10486244; DOI=10.1006/bbrc.1999.1298;
RA Ashiuchi M., Soda K., Misono H.;
RT "A poly-gamma-glutamate synthetic system of Bacillus subtilis IFO 3336:
RT gene cloning and biochemical analysis of poly-gammma-glutamate produced by
RT Escherichia coli clone cells.";
RL Biochem. Biophys. Res. Commun. 263:6-12(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Asahikawa;
RA Tran L.P., Itoh Y.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=NBRC 16449;
RX PubMed=11751809; DOI=10.1128/jb.184.2.337-343.2002;
RA Urushibata Y., Tokuyama S., Tahara Y.;
RT "Characterization of the Bacillus subtilis ywsC gene, involved in gamma-
RT polyglutamic acid production.";
RL J. Bacteriol. 184:337-343(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Required for PGA (gamma-polyglutamic acid) biosynthesis.
CC {ECO:0000269|PubMed:11751809}.
CC -!- DISRUPTION PHENOTYPE: Cells fail to secrete PGA into the medium.
CC {ECO:0000269|PubMed:11751809}.
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DR EMBL; Z92954; CAB07468.1; -; Genomic_DNA.
DR EMBL; AB016245; BAA85264.1; -; Genomic_DNA.
DR EMBL; AB039950; BAB13485.1; -; Genomic_DNA.
DR EMBL; AB046355; BAB40949.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15606.1; -; Genomic_DNA.
DR PIR; G70069; G70069.
DR RefSeq; NP_391470.1; NC_000964.3.
DR RefSeq; WP_003227889.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P96737; -.
DR STRING; 224308.BSU35890; -.
DR PaxDb; P96737; -.
DR EnsemblBacteria; CAB15606; CAB15606; BSU_35890.
DR GeneID; 936840; -.
DR KEGG; bsu:BSU35890; -.
DR PATRIC; fig|224308.179.peg.3885; -.
DR eggNOG; ENOG50301E5; Bacteria.
DR InParanoid; P96737; -.
DR OMA; CITYVIL; -.
DR BioCyc; BSUB:BSU35890-MON; -.
DR PRO; PR:P96737; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR008338; Capsule_biosynth_CapC.
DR Pfam; PF14102; Caps_synth_CapC; 1.
DR PRINTS; PR01759; CAPSULEPROTC.
DR TIGRFAMs; TIGR04011; poly_gGlu_PgsC; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..149
FT /note="PGA biosynthesis protein CapC"
FT /id="PRO_0000089311"
FT VARIANT 57
FT /note="T -> I (in strain: IFO 16449)"
FT VARIANT 138..139
FT /note="AT -> RA (in strain: IFO 16449)"
SQ SEQUENCE 149 AA; 16303 MW; 1C10F36C090110AD CRC64;
MFGSDLYIAL ILGVLLSLIF AEKTGIVPAG LVVPGYLGLV FNQPVFILLV LLVSLLTYVI
VKYGLSKFMI LYGRRKFAAM LITGIVLKIA FDFLYPIVPF EIAEFRGIGI IVPGLIANTI
QKQGLTITFG STLLLSGATF AIMFVYYLI
