ID   CAPD_RICAH              Reviewed;         341 AA.
AC   A8GN21;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=A1C_02485;
OS   Rickettsia akari (strain Hartford).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=293614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hartford;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia akari.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000847; ABV74796.1; -; Genomic_DNA.
DR   RefSeq; WP_012149430.1; NC_009881.1.
DR   AlphaFoldDB; A8GN21; -.
DR   SMR; A8GN21; -.
DR   STRING; 293614.A1C_02485; -.
DR   EnsemblBacteria; ABV74796; ABV74796; A1C_02485.
DR   KEGG; rak:A1C_02485; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   Proteomes; UP000006830; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314599"
SQ   SEQUENCE   341 AA;  38285 MW;  CC8EAEC7FA93B4DC CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSDII NDIKEIRIFS RDEKKQEDMR IALSNPKLKF
     YIGDVRNYKS IDEAMRGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAINNKV
     AKVIVLSTDK AVYPINAMGL SKALMEKLSI AKARMCSQGE TVLCVTRYGN VMASRGSVIP
     LFINQIKQGK ELTITEPSMT RFLMSLVDSV DLVLYAFEHG RQGDIFVQKS PASTIEILAK
     ALQEIFGSKN KIRFIGTRHG EKHYESLVSS EDMAKADDLG GYYRIPMDGR DLNYAKYFVE
     GEKKVALLED YTSHNTKRLN LEEVKKLLLT LDYIQEELKN A