ID   CAPD_RICB8              Reviewed;         341 AA.
AC   A8GWP0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=A1I_04640;
OS   Rickettsia bellii (strain OSU 85-389).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=391896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OSU 85-389;
RA   Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.;
RT   "Complete genome sequencing of Rickettsia bellii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000849; ABV79267.1; -; Genomic_DNA.
DR   RefSeq; WP_012151938.1; NC_009883.1.
DR   AlphaFoldDB; A8GWP0; -.
DR   SMR; A8GWP0; -.
DR   KEGG; rbo:A1I_04640; -.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314600"
SQ   SEQUENCE   341 AA;  38654 MW;  E283E08C3DFC0FA2 CRC64;
     MFVDKTLLIT GGTGSFGNAV LSRFLKNDII KDIKEIRIFS RDEKKQEDMR IALNNPKIKF
     YIGDVRNYNS IDDAMKDVDY VFHAAALKQV PTCEFYPMEA INTNILGAEN VLRAATINKV
     AKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMNVRDK TVFCVTRYGN VMASRGSVIP
     LFINQIKQNK DLTITEPSMT RFLMSLVDSV DLVLYAFEYG HQGDIFVQKS PASTIEVLAK
     ALQGIFNSKN KIRFIGTRHG EKHYESLVSS EEMAKAEDLG NYYRIPMDGR DLNYAKYFVE
     GEKKIALLED YTSHNTKRLN LEEVKELLLN LDYVQEELKN A