ID   XYLH_ECOLI              Reviewed;         393 AA.
AC   P0AGI4; P37389; Q2M7N1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Xylose transport system permease protein XylH;
GN   Name=xylH; OrderedLocusNames=b3568, JW3540;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for D-
CC       xylose. Probably responsible for the translocation of the substrate
CC       across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR   EMBL; U00039; AAB18545.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76592.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77725.1; -; Genomic_DNA.
DR   PIR; S47789; S47789.
DR   RefSeq; NP_418025.1; NC_000913.3.
DR   RefSeq; WP_000045978.1; NZ_STEB01000018.1.
DR   AlphaFoldDB; P0AGI4; -.
DR   BioGRID; 4262543; 15.
DR   BioGRID; 852391; 3.
DR   ComplexPortal; CPX-4388; Xylose ABC transporter complex.
DR   IntAct; P0AGI4; 3.
DR   STRING; 511145.b3568; -.
DR   TCDB; 3.A.1.2.4; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P0AGI4; -.
DR   PRIDE; P0AGI4; -.
DR   EnsemblBacteria; AAC76592; AAC76592; b3568.
DR   EnsemblBacteria; BAE77725; BAE77725; BAE77725.
DR   GeneID; 67417213; -.
DR   GeneID; 948083; -.
DR   KEGG; ecj:JW3540; -.
DR   KEGG; eco:b3568; -.
DR   PATRIC; fig|1411691.4.peg.3144; -.
DR   EchoBASE; EB2185; -.
DR   eggNOG; COG4214; Bacteria.
DR   HOGENOM; CLU_028880_2_0_6; -.
DR   InParanoid; P0AGI4; -.
DR   OMA; FRTQAVQ; -.
DR   PhylomeDB; P0AGI4; -.
DR   BioCyc; EcoCyc:XYLH-MON; -.
DR   BioCyc; MetaCyc:XYLH-MON; -.
DR   PRO; PR:P0AGI4; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042732; P:D-xylose metabolic process; IMP:EcoCyc.
DR   GO; GO:0015753; P:D-xylose transmembrane transport; IC:ComplexPortal.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..393
FT                   /note="Xylose transport system permease protein XylH"
FT                   /id="PRO_0000060234"
FT   TOPO_DOM        1..24
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..102
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..175
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..214
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..239
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..287
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309..312
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        334..336
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        358..365
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        387..393
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  41031 MW;  2BE94243CEDC2C9F CRC64;
     MSKSNPSEVK LAVPTSGGFS GLKSLNLQVF VMIAAIIAIM LFFTWTTDGA YLSARNVSNL
     LRQTAITGIL AVGMVFVIIS AEIDLSVGSM MGLLGGVAAI CDVWLGWPLP LTIIVTLVLG
     LLLGAWNGWW VAYRKVPSFI VTLAGMLAFR GILIGITNGT TVSPTSAAMS QIGQSYLPAS
     TGFIIGALGL MAFVGWQWRG RMRRQALGLQ SPASTAVVGR QALTAIIVLG AIWLLNDYRG
     VPTPVLLLTL LLLGGMFMAT RTAFGRRIYA IGGNLEAARL SGINVERTKL AVFAINGLMV
     AIAGLILSSR LGAGSPSAGN IAELDAIAAC VIGGTSLAGG VGSVAGAVMG AFIMASLDNG
     MSMMDVPTFW QYIVKGAILL LAVWMDSATK RRS