ID   XYLH_SULAC              Reviewed;         356 AA.
AC   Q4J711;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Xylose/arabinose import permease protein XylH {ECO:0000305};
GN   Name=xylH {ECO:0000303|PubMed:29150511};
GN   OrderedLocusNames=Saci_2121 {ECO:0000312|EMBL:AAY81414.1};
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [2]
RP   FUNCTION, SUBUNIT, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=MW001;
RX   PubMed=29150511; DOI=10.1128/aem.01273-17;
RA   Wagner M., Shen L., Albersmeier A., van der Kolk N., Kim S., Cha J.,
RA   Braesen C., Kalinowski J., Siebers B., Albers S.V.;
RT   "Sulfolobus acidocaldarius transports pentoses via a carbohydrate uptake
RT   transporter 2 (CUT2)-type ABC transporter and metabolizes them through the
RT   aldolase-independent Weimberg pathway.";
RL   Appl. Environ. Microbiol. 84:0-0(2018).
CC   -!- FUNCTION: Part of the ABC transporter complex XylFGH involved in the
CC       uptake of xylose and arabinose (PubMed:29150511). Responsible for the
CC       translocation of the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:29150511, ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (XylG),
CC       two transmembrane proteins (XylH) and a solute-binding protein (XylF).
CC       {ECO:0000305|PubMed:29150511}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Up-regulated in the presence of D-xylose, L-arabinose and D-
CC       arabinose. {ECO:0000269|PubMed:29150511}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene results in a growth defect
CC       on D-xylose and L-arabinose. {ECO:0000269|PubMed:29150511}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; CP000077; AAY81414.1; -; Genomic_DNA.
DR   RefSeq; WP_011278916.1; NC_007181.1.
DR   AlphaFoldDB; Q4J711; -.
DR   STRING; 330779.Saci_2121; -.
DR   EnsemblBacteria; AAY81414; AAY81414; Saci_2121.
DR   GeneID; 3472850; -.
DR   KEGG; sai:Saci_2121; -.
DR   PATRIC; fig|330779.12.peg.2126; -.
DR   eggNOG; arCOG00263; Archaea.
DR   HOGENOM; CLU_028880_0_1_2; -.
DR   OMA; FDVWNKR; -.
DR   BRENDA; 7.5.2.13; 6160.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..356
FT                   /note="Xylose/arabinose import permease protein XylH"
FT                   /id="PRO_0000449395"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   356 AA;  38179 MW;  61871C8202BF30F4 CRC64;
     MNILNVVRRF EFQLFLVNVI IALFFYFENS AYFSSNNITT IFQYLAEIGI IAIGEAMLML
     CGEIDLSPPA LANFVPLITL TIYNSIYQAI SPTPAIVVSI LLSLGLASLI GLMNGLITTK
     AKVNSLITTV GTLFLFNGIA LIYSGGYPES FPYFRFLGGT VSILPVPFIW SLGALVFLIL
     LLHYTKIGVW TIAAGSNPTG ASEVGVPVDR VKIINFIIMA NIGALVGIIQ GSRVLTIGAT
     NFTADVVLEG IAAAVIGGTS LVGGKGSLVG AFLGSVFISE LLNGFNILGI NAYEFDAILG
     GAIVVVMVLS YYAKRASYKL KSIATATSSS PEGKDRITKI LKFKIQKIYR RVEENE