ID   CAPD_RICCK              Reviewed;         341 AA.
AC   A8EZA9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=A1E_03815;
OS   Rickettsia canadensis (strain McKiel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=293613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=McKiel;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia canadensis.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000409; ABV73692.1; -; Genomic_DNA.
DR   RefSeq; WP_012148887.1; NC_009879.1.
DR   AlphaFoldDB; A8EZA9; -.
DR   SMR; A8EZA9; -.
DR   STRING; 293613.A1E_03815; -.
DR   EnsemblBacteria; ABV73692; ABV73692; A1E_03815.
DR   KEGG; rcm:A1E_03815; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   OrthoDB; 662797at2; -.
DR   Proteomes; UP000007056; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314602"
SQ   SEQUENCE   341 AA;  38349 MW;  B57C62589A32EA08 CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFIESDII NDIKEIRIFS RDEKKQEDMR IALSNPKLKF
     YIGDVRNYKS VDEAMHGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAIKNKV
     AKVVVLSTDK AVYPVNVMGL SKALMEKLAI AKARMRSMNE TVLCVTRYGN VMASRGSVIP
     LFINQIKQGK ELTITEPSMT RFLMSLVDSV NLVLYAFEHG RQGDIFVQKS PASTIAVLAK
     ALQDIFGSKN KIRFIGTRHG EKHYESLVSS EDMAKAEDLG DYYRIPMDGR DLNYAKYFVE
     GEKKVALLDD YTSHNTRRLN LEEVKELLLT LNYVQEELKN A