XYLL2_ARATH
ID XYLL2_ARATH Reviewed; 503 AA.
AC Q6AWX0; F4KFK8; Q9LFK1;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=D-xylose-proton symporter-like 2;
GN OrderedLocusNames=At5g17010; ORFNames=F2K13.160;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=cv. Columbia;
RX PubMed=19245862; DOI=10.1016/j.jprot.2009.02.004;
RA Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E.,
RA Rathjen J.P., Peck S.C.;
RT "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis
RT thaliana.";
RL J. Proteomics 72:439-451(2009).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q6AWX0-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC01714.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL391141; CAC01714.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED92369.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92370.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92372.2; -; Genomic_DNA.
DR EMBL; BT015128; AAT85724.1; -; mRNA.
DR EMBL; AK228392; BAF00329.1; -; mRNA.
DR PIR; T51556; T51556.
DR RefSeq; NP_001318578.1; NM_001343477.1. [Q6AWX0-1]
DR RefSeq; NP_197203.1; NM_121707.3.
DR RefSeq; NP_850835.2; NM_180504.3. [Q6AWX0-1]
DR RefSeq; NP_850836.2; NM_180505.3. [Q6AWX0-1]
DR AlphaFoldDB; Q6AWX0; -.
DR SMR; Q6AWX0; -.
DR BioGRID; 16840; 12.
DR IntAct; Q6AWX0; 12.
DR STRING; 3702.AT5G17010.1; -.
DR iPTMnet; Q6AWX0; -.
DR PaxDb; Q6AWX0; -.
DR PRIDE; Q6AWX0; -.
DR ProteomicsDB; 242458; -. [Q6AWX0-1]
DR EnsemblPlants; AT5G17010.1; AT5G17010.1; AT5G17010. [Q6AWX0-1]
DR EnsemblPlants; AT5G17010.3; AT5G17010.3; AT5G17010. [Q6AWX0-1]
DR EnsemblPlants; AT5G17010.4; AT5G17010.4; AT5G17010. [Q6AWX0-1]
DR GeneID; 831564; -.
DR Gramene; AT5G17010.1; AT5G17010.1; AT5G17010. [Q6AWX0-1]
DR Gramene; AT5G17010.3; AT5G17010.3; AT5G17010. [Q6AWX0-1]
DR Gramene; AT5G17010.4; AT5G17010.4; AT5G17010. [Q6AWX0-1]
DR KEGG; ath:AT5G17010; -.
DR Araport; AT5G17010; -.
DR TAIR; locus:2148201; AT5G17010.
DR eggNOG; KOG0254; Eukaryota.
DR InParanoid; Q6AWX0; -.
DR OMA; WLFANAG; -.
DR PhylomeDB; Q6AWX0; -.
DR PRO; PR:Q6AWX0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6AWX0; baseline and differential.
DR Genevisible; Q6AWX0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR GO; GO:0015755; P:fructose transmembrane transport; IBA:GO_Central.
DR GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Membrane; Phosphoprotein;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..503
FT /note="D-xylose-proton symporter-like 2"
FT /id="PRO_0000259880"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19245862"
SQ SEQUENCE 503 AA; 53538 MW; 0D404AC956E739BB CRC64;
MALDPEQQQP ISSVSREFGK SSGEISPERE PLIKENHVPE NYSVVAAILP FLFPALGGLL
YGYEIGATSC ATISLQSPSL SGISWYNLSS VDVGLVTSGS LYGALFGSIV AFTIADVIGR
RKELILAALL YLVGALVTAL APTYSVLIIG RVIYGVSVGL AMHAAPMYIA ETAPSPIRGQ
LVSLKEFFIV LGMVGGYGIG SLTVNVHSGW RYMYATSVPL AVIMGIGMWW LPASPRWLLL
RVIQGKGNVE NQREAAIKSL CCLRGPAFVD SAAEQVNEIL AELTFVGEDK EVTFGELFQG
KCLKALIIGG GLVLFQQITG QPSVLYYAPS ILQTAGFSAA GDATRVSILL GLLKLIMTGV
AVVVIDRLGR RPLLLGGVGG MVVSLFLLGS YYLFFSASPV VAVVALLLYV GCYQLSFGPI
GWLMISEIFP LKLRGRGLSL AVLVNFGANA LVTFAFSPLK ELLGAGILFC GFGVICVLSL
VFIFFIVPET KGLTLEEIEA KCL
