ID   CAPD_RICCN              Reviewed;         341 AA.
AC   Q92IG3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=RC0457;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AE006914; AAL02995.1; -; Genomic_DNA.
DR   PIR; A97757; A97757.
DR   RefSeq; WP_010977101.1; NC_003103.1.
DR   AlphaFoldDB; Q92IG3; -.
DR   SMR; Q92IG3; -.
DR   EnsemblBacteria; AAL02995; AAL02995; RC0457.
DR   KEGG; rco:RC0457; -.
DR   PATRIC; fig|272944.4.peg.523; -.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314603"
SQ   SEQUENCE   341 AA;  38411 MW;  DF25AB9C77C040FF CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSGII NDIKEIRIFS RDEKKQEDMR IALNNPKLKF
     YIGDVRNYKS IDEAMHGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAINNKV
     TKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMRSPGE TVLCVTRYGN VMASRGSVIP
     LFINQIKQGK VLTITEPSMT RFLMSLVDSV DLVLYAFEHG HQGDIFVQKS PASTIEVLAK
     ALQDIFDSKN EIRFIGTRHG EKHYESLVSS EEMAKADDLR DYYRIPMDGR DLNYAKYFVE
     GEKKVALLED YTSHNTKRLN LEEVKELLLT LDYVQEELKN A