ID   XYLP_LACPE              Reviewed;         479 AA.
AC   P96792;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Isoprimeverose transporter {ECO:0000303|PubMed:9683504};
DE   AltName: Full=Isoprimeverose cation symporter {ECO:0000303|PubMed:9683504};
GN   Name=xylP {ECO:0000303|PubMed:9573180};
OS   Lactiplantibacillus pentosus (Lactobacillus pentosus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=1589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=MD353;
RX   PubMed=9573180; DOI=10.1128/jb.180.9.2312-2320.1998;
RA   Chaillou S., Lokman B.C., Leer R.J., Posthuma C., Postma P.W.,
RA   Pouwels P.H.;
RT   "Cloning, sequence analysis, and characterization of the genes involved in
RT   isoprimeverose metabolism in Lactobacillus pentosus.";
RL   J. Bacteriol. 180:2312-2320(1998).
RN   [2]
RP   SEQUENCE REVISION.
RA   Chaillou S., Lokman B.C., Leer R.J., Posthuma C., Postma P.W.,
RA   Pouwels P.H.;
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION AS A SYMPORTER.
RX   PubMed=9683504; DOI=10.1128/jb.180.15.4011-4014.1998;
RA   Chaillou S., Postma P.W., Pouwels P.H.;
RT   "Functional expression in Lactobacillus plantarum of xylP encoding the
RT   isoprimeverose transporter of Lactobacillus pentosus.";
RL   J. Bacteriol. 180:4011-4014(1998).
CC   -!- FUNCTION: Involved in the metabolism of isoprimeverose (PubMed:9573180,
CC       PubMed:9683504). Transports isoprimeverose into the cell. Transport is
CC       driven by the proton motive force generated by malolactic fermentation.
CC       Cannot transport D-xylose (PubMed:9683504).
CC       {ECO:0000269|PubMed:9573180, ECO:0000269|PubMed:9683504}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is negatively regulated by XylR and is subject to
CC       CcpA-dependent catabolite repression. {ECO:0000269|PubMed:9573180}.
CC   -!- DISRUPTION PHENOTYPE: XylP-xylQ double mutant retains the ability to
CC       ferment xylose but is impaired in its ability to ferment
CC       isoprimeverose. {ECO:0000269|PubMed:9573180}.
CC   -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC       family. {ECO:0000305}.
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DR   EMBL; U89276; AAC62250.1; -; Genomic_DNA.
DR   AlphaFoldDB; P96792; -.
DR   SMR; P96792; -.
DR   TCDB; 2.A.2.3.3; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IDA:UniProtKB.
DR   GO; GO:0015294; F:solute:cation symporter activity; IDA:UniProtKB.
DR   GO; GO:0034219; P:carbohydrate transmembrane transport; IDA:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001927; Na/Gal_symport.
DR   InterPro; IPR018043; Na/Gal_symport_CS.
DR   PANTHER; PTHR11328; PTHR11328; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00792; gph; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Sugar transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..479
FT                   /note="Isoprimeverose transporter"
FT                   /id="PRO_0000170763"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   479 AA;  52506 MW;  1555AD1084D459C7 CRC64;
     MSVSMQHHSS EASPATQPAS VIHKNMVPWS ERFSYSLSDF ACNLSFSLVS TYLMFFYTDV
     FGISAAIVGT LFLVARIVDA FDGPFWGIMI DHTHTRWGKS RPYWLWFAIP FAVFSVLCFT
     VPNMSTGMKV VWAYVTYIGV DVLYSAVNIP ITSILPSLTS NPQERVTLST IRQFMGTLGA
     TIISTIALPL VAYFGGGSTS SAHGWFMVAL IMAVIAMVIF FIVFANTKER VQTVQSKKSI
     PIKTSLKALK RNWPWVIVIF INFIYWLGMQ TRSQVTVYFF KYNMHDATLA SFILGLQLVA
     LLAVVITPWT AKRIGKRNTM LMGMLLAIVG QLILWGGSKA LNVPTITVGT IVGYLGTGFV
     SGLIAVMLAD SVDYGEWKNG VRAEGIVTSF SSFSAKFGMG IGGAVTGLIL SAGGYVANHA
     QSAQALNAIE MNYVWVPIVG FGLSAIALLF YKVDKIEPKM LADLEQKHAQ ENALADDQK