ID   XYLR_BACSH              Reviewed;         384 AA.
AC   P16557; E0TVS4;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Xylose repressor;
GN   Name=xylR; OrderedLocusNames=BSUW23_09020;
OS   Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) (Bacillus
OS   subtilis subsp. spizizenii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=655816;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 23059 / NRRL B-14472 / W23;
RX   PubMed=2544559; DOI=10.1128/jb.171.7.3840-3845.1989;
RA   Kreuzer P., Gaertner D., Allmansberger R., Hillen W.;
RT   "Identification and sequence analysis of the Bacillus subtilis W23 xylR
RT   gene and xyl operator.";
RL   J. Bacteriol. 171:3840-3845(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23059 / NRRL B-14472 / W23;
RX   PubMed=21527469; DOI=10.1099/mic.0.048520-0;
RA   Zeigler D.R.;
RT   "The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights
RT   into speciation within the B. subtilis complex and into the history of B.
RT   subtilis genetics.";
RL   Microbiology 157:2033-2041(2011).
CC   -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; M27248; AAA22896.1; -; Genomic_DNA.
DR   EMBL; CP002183; ADM37850.1; -; Genomic_DNA.
DR   PIR; A32885; A32885.
DR   AlphaFoldDB; P16557; -.
DR   SMR; P16557; -.
DR   EnsemblBacteria; ADM37850; ADM37850; BSUW23_09020.
DR   KEGG; bss:BSUW23_09020; -.
DR   HOGENOM; CLU_036604_13_2_9; -.
DR   OMA; VDFGHTH; -.
DR   Proteomes; UP000002233; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Xylose metabolism.
FT   CHAIN           1..384
FT                   /note="Xylose repressor"
FT                   /id="PRO_0000095711"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   384 AA;  42296 MW;  E0F87183EAF5A205 CRC64;
     MDIADQTFVK KVNQKLLLKE ILKNSPISRA KLSEMTGLNK STVSSQVNTL MKENLVFEIG
     QGQSSGGRRP VMLVFNKKAG YSIGIDVGVD YISGILTDLE GTIILDQHHH LESNSPEITK
     DILIDMIHHF ITRMPQSPYG LIGIGICVPG LIDKNQKIVF TPNSNWRDID LKSFIQEKFN
     VPVFIENEAN AGAYGEKVFG AAKNHNNIIY ASISTGIGIG VIINNHLYRG VSGFSGEMGH
     MTIDFNGPKC SCGNRGCWEL YASEKALLKS LQTKEKKVSY QDIIDLAHLN DIGTLNALQN
     FGFYLGIGLT NILNTFNPQA IILRNSIIES HPMVLNSIRS EVSSRVYPQL GNSYELLPSS
     LGKNAPALGM SSIVIEHFLD IVKM