XYLR_BACSU
ID XYLR_BACSU Reviewed; 384 AA.
AC P94490; Q796H3;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Xylose repressor;
GN Name=xylR; OrderedLocusNames=BSU17590;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Borchert S., Klein C., Piksa B., Hammelmann M., Entian K.-D.;
RT "Sequencing of a 26 kb region of the Bacillus subtilis genome downstream of
RT spoVJ.";
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hastrup S.;
RT "Gene expression system.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 141; 182 AND 198.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB41092.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U66480; AAB41092.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB13643.3; -; Genomic_DNA.
DR RefSeq; NP_389641.2; NC_000964.3.
DR RefSeq; WP_003244935.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P94490; -.
DR SMR; P94490; -.
DR STRING; 224308.BSU17590; -.
DR PaxDb; P94490; -.
DR PRIDE; P94490; -.
DR EnsemblBacteria; CAB13643; CAB13643; BSU_17590.
DR GeneID; 939531; -.
DR KEGG; bsu:BSU17590; -.
DR PATRIC; fig|224308.179.peg.1909; -.
DR eggNOG; COG1940; Bacteria.
DR InParanoid; P94490; -.
DR OMA; VDFGHTH; -.
DR BioCyc; BSUB:BSU17590-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR18964; PTHR18964; 1.
DR Pfam; PF00480; ROK; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF53067; SSF53067; 1.
DR PROSITE; PS01125; ROK; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; DNA-binding; Reference proteome; Repressor;
KW Transcription; Transcription regulation; Xylose metabolism.
FT CHAIN 1..384
FT /note="Xylose repressor"
FT /id="PRO_0000095710"
FT DNA_BIND 29..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT CONFLICT 141
FT /note="L -> F (in Ref. 1; AAB41092)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="P -> S (in Ref. 1; AAB41092)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="V -> L (in Ref. 1; AAB41092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 42287 MW; 89784C7841B0B33A CRC64;
MDIADQTFVK KVNQKLLLKE ILKNSPISRA KLSEMTGLNK STVSSQVNTL MKESMVFEIG
QGQSSGGRRP VMLVFNKKAG YSVGIDVGVD YINGILTDLE GTIVLDQYRH LESNSPEITK
DILIDMIHHF ITQMPQSPYG LIGIGICVPG LIDKDQKIVF TPNSNWRDID LKSSIQEKYN
VPVFIENEAN AGAYGEKVFG AAKNHDNIIY VSISTGIGIG VIINNHLYRG VSGFSGEMGH
MTIDFNGPKC SCGNRGCWEL YASEKALLKS LQTKEKKLSY QDIINLAHLN DIGTLNALQN
FGFYLGIGLT NILNTFNPQA VILRNSIIES HPMVLNSMRS EVSSRVYSQL GNSYELLPSS
LGQNAPALGM SSIVIDHFLD MITM
