ID   XYLR_CALBD              Reviewed;         399 AA.
AC   Q44406; B9MPI0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Xylose repressor;
GN   Name=xylR; OrderedLocusNames=Athe_0617;
OS   Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS   (Anaerocellum thermophilum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX   NCBI_TaxID=521460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zverlov V.V., Bronnenmeier K., Velikodvorskaya G.A.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Kataeva I., Adams M.W.W.;
RT   "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; Z69782; CAA93626.1; -; Genomic_DNA.
DR   EMBL; CP001393; ACM59741.1; -; Genomic_DNA.
DR   RefSeq; WP_015907194.1; NC_012034.1.
DR   AlphaFoldDB; Q44406; -.
DR   SMR; Q44406; -.
DR   STRING; 521460.Athe_0617; -.
DR   EnsemblBacteria; ACM59741; ACM59741; Athe_0617.
DR   GeneID; 31771972; -.
DR   KEGG; ate:Athe_0617; -.
DR   eggNOG; COG1940; Bacteria.
DR   HOGENOM; CLU_036604_13_5_9; -.
DR   OMA; VDFGHTH; -.
DR   OrthoDB; 1130699at2; -.
DR   Proteomes; UP000007723; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Xylose metabolism.
FT   CHAIN           1..399
FT                   /note="Xylose repressor"
FT                   /id="PRO_0000095709"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   399 AA;  43968 MW;  7A2DE3435E44F08D CRC64;
     MGNHTLLKQI NKLLVLKTIL DNKIISRTKI SKLVDLNKAT VSNLTDELIK EGYVVEKGYG
     KSKGGRRPVL LQVNKDVGSI IGIDLGVDYI HIILSNFVGE VIFEEYANMK IGEDKEKLLR
     LLFDLIEKSV KKAPQTPKGI LGIGIGVPGI IEKESGTVLL APNLKWQNVP LRSIVQQKFN
     LPVYIDNEAN AGALGEKWFG EWGKVSDLIY LSVGIGLGAG IIIDNKLFRG AAGFAGEVGH
     TTINFQDDVC SCGNIGCLEN FASERALLSV IKKLVKQGVE DRYISWENVD EITPSRIIQA
     AKEGSRVCRM AILEVAEKMG IGVANLVNIF NPEMVIIGNK ASFFGELFLE KLREVINQRS
     FIAQFYNLKI EVSKLKDRAV VLGCIAMVIS DMLSFPEYA