ID   XYLR_CALSR              Reviewed;         399 AA.
AC   P40981;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative xylose repressor;
GN   Name=xylR;
OS   Caldicellulosiruptor sp. (strain Rt8B.4).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor;
OC   unclassified Caldicellulosiruptor.
OX   NCBI_TaxID=28238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8920183; DOI=10.1007/s002530050653;
RA   Dwivedi P.P., Gibbs M.D., Saul D.J., Bergquist P.L.;
RT   "Cloning, sequencing and overexpression in Escherichia coli of a xylanase
RT   gene, xynA from the thermophilic bacterium Rt8B.4 genus
RT   Caldicellulosiruptor.";
RL   Appl. Microbiol. Biotechnol. 45:86-93(1996).
CC   -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; L18965; AAB42043.1; -; Genomic_DNA.
DR   PIR; S41787; S41787.
DR   AlphaFoldDB; P40981; -.
DR   SMR; P40981; -.
DR   PRIDE; P40981; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF01047; MarR; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Xylose metabolism.
FT   CHAIN           1..399
FT                   /note="Putative xylose repressor"
FT                   /id="PRO_0000095712"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   399 AA;  43725 MW;  CCB49FF12AF73F0F CRC64;
     MGNHALIKQI NKLLILKTIL DHRTISRAKI SKLVDLNKAT VSNLTDELIK EGFVIEKGYG
     HSKGGRRPVL LEVNKNVGLI IGIDLGVNYI HLVLTNFIGE IIWERNMAIK LGEKQEKILE
     SLFIILEEAI KAAPPTQKGI LGIGIGVPGI VEKNSGTVLL APNLKWQDVP LKRMVESRFG
     LPVYIDNEAN AGALGEKWFG GWGDVSHLLY VSVGIGIGAG IVIGEEVYRG AKGFAGEVGH
     MTIDFNDDVC SCGNVGCLEN FASERALLSL IKTLVESGVE DEYINRDTVE EMDAGYIIQS
     ALQRSRVAMN AITDIANKLG IGIANLVNIF NPDIVVIGNK ASFMGDLFLE ELRRIVYKRA
     FITQYHHVRV EVSKLKDRAC VLGCVAMVIS DMLAFPDYV