ID   XYLR_ECO57              Reviewed;         392 AA.
AC   P0ACI5; P37390;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Xylose operon regulatory protein;
GN   Name=xylR; OrderedLocusNames=Z4994, ECs4452;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Regulatory protein for the xylBAFGHR operon. {ECO:0000250}.
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DR   EMBL; AE005174; AAG58718.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37875.1; -; Genomic_DNA.
DR   PIR; B86032; B86032.
DR   PIR; D91185; D91185.
DR   RefSeq; NP_312479.1; NC_002695.1.
DR   RefSeq; WP_000494484.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACI5; -.
DR   SMR; P0ACI5; -.
DR   STRING; 155864.EDL933_4834; -.
DR   PRIDE; P0ACI5; -.
DR   EnsemblBacteria; AAG58718; AAG58718; Z4994.
DR   EnsemblBacteria; BAB37875; BAB37875; ECs_4452.
DR   GeneID; 66672542; -.
DR   GeneID; 915610; -.
DR   KEGG; ece:Z4994; -.
DR   KEGG; ecs:ECs_4452; -.
DR   PATRIC; fig|386585.9.peg.4661; -.
DR   eggNOG; COG1609; Bacteria.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_042405_1_0_6; -.
DR   OMA; VEAAFMH; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Xylose operon regulatory protein"
FT                   /id="PRO_0000194598"
FT   DOMAIN          288..386
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        305..326
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        353..376
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   392 AA;  44869 MW;  AAC15819B7FC831A CRC64;
     MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID KIKDWLGDGV
     IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA TDNYALVESA FLHLKEKGVN
     RFAFYGLPES SGKRWATERE YAFRQLVAEE KYRGVVYQGL ETAPENWQHA QNRLADWLQT
     LPPQTGIIAV TDARARHILQ VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR
     QMGYQAAKLL HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK
     GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT LSINEISQMC
     GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML