ID   XYLR_ECOL6              Reviewed;         392 AA.
AC   P0ACI4; P37390;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Xylose operon regulatory protein;
GN   Name=xylR; OrderedLocusNames=c4389;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Regulatory protein for the xylBAFGHR operon. {ECO:0000250}.
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DR   EMBL; AE014075; AAN82825.1; -; Genomic_DNA.
DR   RefSeq; WP_000494484.1; NC_004431.1.
DR   AlphaFoldDB; P0ACI4; -.
DR   SMR; P0ACI4; -.
DR   STRING; 199310.c4389; -.
DR   EnsemblBacteria; AAN82825; AAN82825; c4389.
DR   GeneID; 66672542; -.
DR   KEGG; ecc:c4389; -.
DR   eggNOG; COG1609; Bacteria.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_042405_1_0_6; -.
DR   OMA; VEAAFMH; -.
DR   BioCyc; ECOL199310:C4389-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Xylose operon regulatory protein"
FT                   /id="PRO_0000194599"
FT   DOMAIN          288..386
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        305..326
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        353..376
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   392 AA;  44869 MW;  AAC15819B7FC831A CRC64;
     MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID KIKDWLGDGV
     IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA TDNYALVESA FLHLKEKGVN
     RFAFYGLPES SGKRWATERE YAFRQLVAEE KYRGVVYQGL ETAPENWQHA QNRLADWLQT
     LPPQTGIIAV TDARARHILQ VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR
     QMGYQAAKLL HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK
     GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT LSINEISQMC
     GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML