ID   CAPD_RICFE              Reviewed;         341 AA.
AC   Q4UM33;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=RF_0539;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000053; AAY61390.1; -; Genomic_DNA.
DR   RefSeq; WP_011270871.1; NC_007109.1.
DR   AlphaFoldDB; Q4UM33; -.
DR   SMR; Q4UM33; -.
DR   STRING; 315456.RF_0539; -.
DR   EnsemblBacteria; AAY61390; AAY61390; RF_0539.
DR   KEGG; rfe:RF_0539; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   OrthoDB; 662797at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314604"
SQ   SEQUENCE   341 AA;  38362 MW;  39BB0D5528F5D2E1 CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSDIT NDIKEIRIFS RDEKKQEDMR IALNNPKLKF
     YIGDVRNYKS IDEAMHGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAINNKV
     AKVIVLSTDK AVYPINAMGL SKALMEKLAV AKARMRSQGE TVLCVTRYGN VMASRGSVIP
     LFINQIKQDK DLTITEPSMT RFLMSLVDSV DLVLYAFEHG RQGDIFVQKS PASTIEVLAK
     ALQEIFGSKN ELRFIGTRHG EKHYESLVSS EEMAKADDLG GYYRIPMDGR DLNYAKYFVE
     GEKKVALLED YNSHNTKRLN LEEVKELLLN LDYVQEELKN A