XYLR_ECOLI
ID XYLR_ECOLI Reviewed; 392 AA.
AC P0ACI3; P37390; Q2M7N2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Xylose operon regulatory protein;
GN Name=xylR; OrderedLocusNames=b3569, JW3541;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Regulatory protein for the xylBAFGHR operon.
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DR EMBL; U00039; AAB18546.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76593.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77724.1; -; Genomic_DNA.
DR PIR; S47790; S47790.
DR RefSeq; NP_418026.1; NC_000913.3.
DR RefSeq; WP_000494484.1; NZ_STEB01000018.1.
DR PDB; 4FE4; X-ray; 3.45 A; A/B/C=1-392.
DR PDB; 4FE7; X-ray; 2.90 A; A=1-392.
DR PDBsum; 4FE4; -.
DR PDBsum; 4FE7; -.
DR AlphaFoldDB; P0ACI3; -.
DR SMR; P0ACI3; -.
DR BioGRID; 4262544; 9.
DR STRING; 511145.b3569; -.
DR jPOST; P0ACI3; -.
DR PaxDb; P0ACI3; -.
DR PRIDE; P0ACI3; -.
DR EnsemblBacteria; AAC76593; AAC76593; b3569.
DR EnsemblBacteria; BAE77724; BAE77724; BAE77724.
DR GeneID; 66672542; -.
DR GeneID; 948086; -.
DR KEGG; ecj:JW3541; -.
DR KEGG; eco:b3569; -.
DR PATRIC; fig|1411691.4.peg.3143; -.
DR EchoBASE; EB4154; -.
DR eggNOG; COG1609; Bacteria.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_042405_1_0_6; -.
DR InParanoid; P0ACI3; -.
DR OMA; VEAAFMH; -.
DR PhylomeDB; P0ACI3; -.
DR BioCyc; EcoCyc:EG20253-MON; -.
DR PRO; PR:P0ACI3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:EcoCyc.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..392
FT /note="Xylose operon regulatory protein"
FT /id="PRO_0000194597"
FT DOMAIN 288..386
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 305..326
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 353..376
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 14..16
FT /evidence="ECO:0007829|PDB:4FE4"
FT HELIX 17..33
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 37..41
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 58..63
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 67..73
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 80..85
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 90..92
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 95..101
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 103..116
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 121..125
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 134..147
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 155..157
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 167..180
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 185..191
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 192..205
FT /evidence="ECO:0007829|PDB:4FE7"
FT TURN 209..212
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 213..219
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 224..226
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:4FE4"
FT STRAND 233..236
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 239..254
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 263..266
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 270..272
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 275..277
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 285..297
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 298..300
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 304..310
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 315..326
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 330..348
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 353..359
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 365..375
FT /evidence="ECO:0007829|PDB:4FE7"
FT STRAND 376..378
FT /evidence="ECO:0007829|PDB:4FE7"
FT HELIX 380..387
FT /evidence="ECO:0007829|PDB:4FE7"
SQ SEQUENCE 392 AA; 44869 MW; AAC15819B7FC831A CRC64;
MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID KIKDWLGDGV
IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA TDNYALVESA FLHLKEKGVN
RFAFYGLPES SGKRWATERE YAFRQLVAEE KYRGVVYQGL ETAPENWQHA QNRLADWLQT
LPPQTGIIAV TDARARHILQ VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR
QMGYQAAKLL HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK
GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT LSINEISQMC
GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML
