ID   XYLR_STAXY              Reviewed;         383 AA.
AC   P27159;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Xylose repressor;
GN   Name=xylR;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=1714034; DOI=10.1007/bf00273926;
RA   Sizemore C., Buchner E., Rygus T., Witke C., Goetz F., Hillen W.;
RT   "Organization, promoter analysis and transcriptional regulation of the
RT   Staphylococcus xylosus xylose utilization operon.";
RL   Mol. Gen. Genet. 227:377-384(1991).
CC   -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; X57599; CAA40823.1; -; Genomic_DNA.
DR   PIR; S16529; S16529.
DR   RefSeq; WP_047171713.1; NZ_VBTJ01000002.1.
DR   AlphaFoldDB; P27159; -.
DR   SMR; P27159; -.
DR   STRING; 1288.SXYLSMQ121_0143; -.
DR   eggNOG; COG1846; Bacteria.
DR   eggNOG; COG1940; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Xylose metabolism.
FT   CHAIN           1..383
FT                   /note="Xylose repressor"
FT                   /id="PRO_0000095714"
FT   DNA_BIND        26..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   383 AA;  43376 MW;  601CCD3D3D64ECA1 CRC64;
     MENNFIVNEN EKRVLKQIFN NSNISRTQIS KNLELNKATI SNILNNLKHK SLVNEVGEGN
     STKSGGRKPI LLEINQKYGY YISMDLTYDS VELMYNYFDA TILKQDSYEL NDKNVSSILQ
     ILKSNINVSE KYDTLYGLLG ISISIHGIVD DEQNIINLPF HKNEKRTFTD ELKSFTNVPV
     VIENEANLSA LYEKSLYINS NINNLITLSI HKGIGAGIII NKKLYRGSNG EAGEIGKTLV
     LESINNNDNK YYKIEDICSQ DALIQKINNR LGVTLTFTEL IQYYNEGNSI VAHEIKQFIN
     KMTVLIHNLN TQFNPDAIYI NCPLINELPN ILNEIKEQFS CFSQGSPIQL HLTTNVKQAT
     LLGGTLAIMQ KTLNINNIQM NIK