ID   XYLS3_PSEPU             Reviewed;         331 AA.
AC   Q05335;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=XylDLEGF operon transcriptional activator 3;
GN   Name=xylS3;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid TOL pWW53.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MT53;
RX   PubMed=8473862; DOI=10.1099/00221287-139-3-557;
RA   Assinder S.J., de Marco P., Osborne D.J., Poh C.L., Shaw L.E., Winson M.K.,
RA   Williams P.A.;
RT   "A comparison of the multiple alleles of xylS carried by TOL plasmids pWW53
RT   and pDK1 and its implications for their evolutionary relationship.";
RL   J. Gen. Microbiol. 139:557-568(1993).
CC   -!- FUNCTION: Regulatory protein of the TOL plasmid xyl operons. XylS
CC       activates the xylXYZLTEGFJQKIH operon required for the degradation of
CC       toluene, m-xylene and p-xylene.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
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DR   EMBL; L02357; AAA26032.1; -; Genomic_DNA.
DR   RefSeq; WP_011600770.1; NZ_MING01000087.1.
DR   RefSeq; YP_709341.1; NC_008275.1.
DR   AlphaFoldDB; Q05335; -.
DR   SMR; Q05335; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR   InterPro; IPR035418; AraC-bd_2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF14525; AraC_binding_2; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; Aromatic hydrocarbons catabolism; Cytoplasm; DNA-binding;
KW   Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..331
FT                   /note="XylDLEGF operon transcriptional activator 3"
FT                   /id="PRO_0000194604"
FT   DOMAIN          214..315
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        231..252
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        282..305
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   331 AA;  37847 MW;  10A2C4EDBD362A72 CRC64;
     MDCRLLNEKS RIFVNADPYF VSDYVNQHVG SHCIRLPKSG CPEASLNHST FGSLDLCRIS
     YGGSVRVTSP GLETCYHLQV LLKGHCLWRG YGLEHYFSPG ELLLINPDDR ADLTYSEDCE
     KFIVKLPSVV LDRACSESYW HKPSEGIRFT TRHNLQQLDG FINLLGLVCD EAEHTNSMPR
     VQEYYTGIIA TKLLEMLSSN VSRETFSEGC PSFERVVQFI EDNLKQSISL ERLAELALMS
     PRSLYTLFEK HAGTTPKNYI RNRKLECIRA RLSDPNANVR SVTEMALDYG FFHTGRFAEN
     YRSTFGELPS DTLRRRKMKW LDPEESLPPL P