ID   CAPD_RICM5              Reviewed;         341 AA.
AC   A8F1A5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=RMA_0474;
OS   Rickettsia massiliae (strain Mtu5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=416276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mtu5;
RX   PubMed=17916642; DOI=10.1101/gr.6742107;
RA   Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.;
RT   "Lateral gene transfer between obligate intracellular bacteria: evidence
RT   from the Rickettsia massiliae genome.";
RL   Genome Res. 17:1657-1664(2007).
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABV84691.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000683; ABV84691.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014365967.1; NC_009900.1.
DR   AlphaFoldDB; A8F1A5; -.
DR   SMR; A8F1A5; -.
DR   EnsemblBacteria; ABV84691; ABV84691; RMA_0474.
DR   KEGG; rms:RMA_0474; -.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   Proteomes; UP000001311; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314605"
SQ   SEQUENCE   341 AA;  38489 MW;  796E910C421B6583 CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSDII NDIKEIRIFS RDEKKQEDMR IAFNNPKLKC
     YIGDVRNYKS IDEAMHGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAINNKV
     TKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMRSPGE TVLCVTRYGN VMASRGSVIP
     LFINQIKQGK ELTITEPSMT RFLMSLVDSV DLVLYAFEHG HQGDIFVQKS PASTIEVLAK
     ALQDIFDSKN EIRFIGTRHG EKHYESLVSS EEMAKADDLR DYYRIPMDGR DLNYAKYFVE
     GEKKVALLED YTSHNTKRLN LEEVKELLLT LDYVQEELKN A