ID   CAPD_RICRS              Reviewed;         341 AA.
AC   A8GRN9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=A1G_02595;
OS   Rickettsia rickettsii (strain Sheila Smith).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=392021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheila Smith;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia rickettsii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000848; ABV76064.1; -; Genomic_DNA.
DR   RefSeq; WP_012150660.1; NC_009882.1.
DR   AlphaFoldDB; A8GRN9; -.
DR   SMR; A8GRN9; -.
DR   EnsemblBacteria; ABV76064; ABV76064; A1G_02595.
DR   KEGG; rri:A1G_02595; -.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   Proteomes; UP000006832; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314607"
SQ   SEQUENCE   341 AA;  38436 MW;  EE6FA87DC70BC898 CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSGII NDIKEIRIFS RDEKKQEDMR IALNNPKLKF
     YIGDVRNYKS IDEAMHGVNY VFHAAALKQV PTCEFYPMEA INTNVLGTEN VLSAAINNKV
     TKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMRSSGE TVLCVTRYGN VMASRGSVIP
     LFINQIKQGK ELTITEPSMT RFLMSLVDSV DLVLYAFEHG NQGDIFVQKS PASTIEVLAK
     ALQDIFNSKN EIRFIGTRHG EKHYESLVSS EEMAKADDLR DYYRIPMDGR DLNYAKYFVE
     GEKKVALLED YTSHNTKRLN LEEVKELLLT LDYVQEELKN A