ID   CAPD_RICTY              Reviewed;         341 AA.
AC   Q8L2J6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=RT0323;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ethiopian AZ322;
RA   Rahman M.S., Radulovic S., Azad A.F.;
RT   "Molecular characterization of Rickettsia typhi capD gene.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AF503337; AAM22229.1; -; Genomic_DNA.
DR   EMBL; AE017197; AAU03803.1; -; Genomic_DNA.
DR   RefSeq; WP_011190787.1; NC_006142.1.
DR   AlphaFoldDB; Q8L2J6; -.
DR   SMR; Q8L2J6; -.
DR   STRING; 257363.RT0323; -.
DR   EnsemblBacteria; AAU03803; AAU03803; RT0323.
DR   KEGG; rty:RT0323; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OMA; HEVMIPK; -.
DR   OrthoDB; 662797at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314608"
SQ   SEQUENCE   341 AA;  38278 MW;  57B347ECE06FF8EC CRC64;
     MFVDKTLMIT GGTGSFGNAV LSRFLKSNII NDIKEIRIFS RDEKKQEDMR IALNHSKLKF
     YIGDVRNYQS IDDAMHGVDY VFHAAALKQV PTCEFYPMEA INTNVLGAEN VLSAAINNKV
     TKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMRSPGE TILCVTRYGN VMASRGSVIP
     LFIHQIKQGK ELTITEPSMT RFLMSLVDSV DLVLYAFEHG RQGDIFVQKS PASTIEVLAK
     ALQEIFGSKN AIRFIGTRHG EKHYESLVSS EDMAKADDLG GYYRIPMDGR DLNYAKYFVE
     GEKKVALLKD YTSHNTKRLN LKEVKELLLT LDYVQEELKN A