ID   CAPD_STAAU              Reviewed;         599 AA.
AC   P39853;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CapD;
GN   Name=capD;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49951 / M / NCTC 10649;
RX   PubMed=7961465; DOI=10.1128/jb.176.22.7005-7016.1994;
RA   Lin W.S., Cunneen T., Lee C.Y.;
RT   "Sequence analysis and molecular characterization of genes required for the
RT   biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus.";
RL   J. Bacteriol. 176:7005-7016(1994).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U10927; AAA64643.1; -; Genomic_DNA.
DR   AlphaFoldDB; P39853; -.
DR   SMR; P39853; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..599
FT                   /note="Capsular polysaccharide biosynthesis protein CapD"
FT                   /id="PRO_0000166445"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   599 AA;  67562 MW;  11ECBB26D729E6DB CRC64;
     MTSISAKLRF LILIIIDSFI VTFSVFLGYA ILEPYFKGYS IDLLVLSSVI LLVSHHIFAY
     VFNLYHRAWE YASVSELMSV LKAVTSSIVV TLLLVSLLIS ESPFLRLYFI TWMMHLLLIG
     GSRLFWRVYR RYFIDNAVEK KATLVVGAGQ GGSVLIREML RSQDMRMQPV LAVDDDKNKQ
     KMTITERVKV QGYVEDIPEL VKKFRIKKII IAIPTLSQKR LNEINKICNI EGVELFKMPN
     IEDVLSGELE VNNLKKVEVE DLLGRDPVEL DMALISRELT NKTILVTGAG GSIGSEICRQ
     VSKFDPQKII LLGHGENSIY SIHQELSKTY GNRIEFVPVI ADVQNKTRIL EVMNEFKPYA
     VYHAAAHKHV PLMEYNPHEA IRNNILGTKN VAESAKEGEV SKFVMISTDK AVNPSNVMGA
     TKRIAEMVIQ SLNEDNSKTS FVAVRFGNVL GSRGSVIPLF KNQIESGGPV TVTHPEMTRY
     FMTIPEASRL VLQAGALAQG GEVFVLDMGK PVKIVDLAKN LIRLSGKKEE DIGIEFSGIR
     PGEKLYEELL NKNEIHPQQV YEKIYRGKVD HYIKTEVDLI VEDLINNFSK EKLLKIANR