ID   CAPF_STAAU              Reviewed;         396 AA.
AC   P39855;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CapF;
GN   Name=capF;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49951 / M / NCTC 10649;
RX   PubMed=7961465; DOI=10.1128/jb.176.22.7005-7016.1994;
RA   Lin W.S., Cunneen T., Lee C.Y.;
RT   "Sequence analysis and molecular characterization of genes required for the
RT   biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus.";
RL   J. Bacteriol. 176:7005-7016(1994).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; U10927; AAA64645.1; -; Genomic_DNA.
DR   AlphaFoldDB; P39855; -.
DR   SMR; P39855; -.
DR   TCDB; 2.A.66.2.5; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002797; Polysacc_synth.
DR   Pfam; PF01943; Polysacc_synt; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..396
FT                   /note="Capsular polysaccharide biosynthesis protein CapF"
FT                   /id="PRO_0000166446"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   396 AA;  44993 MW;  A9D2796CF2B5EB75 CRC64;
     MVKNFNYMFV ANILSALCKF LILLVIVRLG TPEDVGRYNY ALVITAPIFL FISLKIRSVI
     VTNDKYSPNE YISAILSLNI ITLIFVAIFV YVLGNGDLTT ILIVSLIKLF ENIKEVPYGI
     YQKNESLKLL GISMGIYNIL SLILFYIIYS FSHNLNMALL FLVISCIFSF AIIDRWYLSK
     YYNIKLHYNN NIAKFKEIFI LTIPLAFSSA LGSLNTGIPR IVLENLFGKY TLGIFSTIAY
     VLVIGGLFAN SISQVFLPKL RKLYKDEKKI EFEKLTRKMV FIGIFIGMCS VILSLFLGEA
     LLSLLFGKEY GENNIILIIL SFGLLFILSG IFLGTTIIAT GKYNVNYKIS LILLFCILIF
     SFLLIPKYSL LGAALTITIS QFVALISYYY FYKRIF