ID   CAPI_STAAU              Reviewed;         334 AA.
AC   P39858;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein CapI;
DE            EC=4.-.-.-;
GN   Name=capI;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49951 / M / NCTC 10649;
RX   PubMed=7961465; DOI=10.1128/jb.176.22.7005-7016.1994;
RA   Lin W.S., Cunneen T., Lee C.Y.;
RT   "Sequence analysis and molecular characterization of genes required for the
RT   biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus.";
RL   J. Bacteriol. 176:7005-7016(1994).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; U10927; AAA64648.1; -; Genomic_DNA.
DR   AlphaFoldDB; P39858; -.
DR   SMR; P39858; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Exopolysaccharide synthesis; Lyase; NAD.
FT   CHAIN           1..334
FT                   /note="Protein CapI"
FT                   /id="PRO_0000183255"
FT   ACT_SITE        151
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         126
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   334 AA;  37931 MW;  2FDFBF8D4D7796CF CRC64;
     MKILITGTAG FIGSHLAKKL IKQGHYVIGV DSINDYYSVS LKEDRLKSIG KENFTFNKVK
     LENYDDLSKV FVDEQPEVVV NLAAQAGVRY SIENPRTYID SNIVGFMNIL ECSRHFNIQN
     LIYASSSSVY GANTSKPFST SDNIDHPLSL YAATKKSNEL MAHTYSHLYN LPTTGLRFFT
     VYGPWGRPDM ALFKFTKAIV NDQAIDVYNH GNMMRDFTYV DDIVEAISRL VKKPASPNKE
     WSGADPDPGS SYAPYKVYNI GNNSPVRLME FVEAIENKLG KEARKNYMDL QPGDVPETYA
     NVDDLFRDID FKPETTIQDG VNKFVDWYLE YYKK