XYNC_ASPNC
ID XYNC_ASPNC Reviewed; 327 AA.
AC A2QFV7;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Probable endo-1,4-beta-xylanase C;
DE Short=Xylanase C;
DE EC=3.2.1.8;
DE AltName: Full=1,4-beta-D-xylan xylanohydrolase C;
DE Flags: Precursor;
GN Name=xlnC; Synonyms=xynA; ORFNames=An03g00940;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a
CC major structural heterogeneous polysaccharide found in plant biomass
CC representing the second most abundant polysaccharide in the biosphere,
CC after cellulose. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.;
CC EC=3.2.1.8;
CC -!- PATHWAY: Glycan degradation; xylan degradation.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- INDUCTION: Expressed in presence of xylan and repressed by glucose.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
CC {ECO:0000305}.
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DR EMBL; AM270045; CAK38067.1; -; Genomic_DNA.
DR PDB; 4XUY; X-ray; 2.00 A; A/B=27-327.
DR PDBsum; 4XUY; -.
DR AlphaFoldDB; A2QFV7; -.
DR SMR; A2QFV7; -.
DR CAZy; GH10; Glycoside Hydrolase Family 10.
DR PaxDb; A2QFV7; -.
DR PRIDE; A2QFV7; -.
DR EnsemblFungi; CAK38067; CAK38067; An03g00940.
DR VEuPathDB; FungiDB:An03g00940; -.
DR HOGENOM; CLU_020161_2_0_1; -.
DR UniPathway; UPA00114; -.
DR Proteomes; UP000006706; Chromosome 6R.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0031176; F:endo-1,4-beta-xylanase activity; IDA:AspGD.
DR GO; GO:0045493; P:xylan catabolic process; IDA:AspGD.
DR InterPro; IPR044846; GH10.
DR InterPro; IPR031158; GH10_AS.
DR InterPro; IPR001000; GH10_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR31490; PTHR31490; 1.
DR Pfam; PF00331; Glyco_hydro_10; 1.
DR PRINTS; PR00134; GLHYDRLASE10.
DR SMART; SM00633; Glyco_10; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS00591; GH10_1; 1.
DR PROSITE; PS51760; GH10_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Disulfide bond; Glycosidase;
KW Hydrolase; Polysaccharide degradation; Reference proteome; Secreted;
KW Signal; Xylan degradation.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..327
FT /note="Probable endo-1,4-beta-xylanase C"
FT /id="PRO_5000219726"
FT DOMAIN 55..326
FT /note="GH10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01096"
FT ACT_SITE 157
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 263
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10061"
FT DISULFID 281..287
FT /evidence="ECO:0000250"
FT HELIX 31..36
FT /evidence="ECO:0007829|PDB:4XUY"
FT TURN 37..39
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 41..47
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 49..53
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 54..56
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 57..65
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 67..73
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 90..101
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 105..116
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 119..122
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 127..144
FT /evidence="ECO:0007829|PDB:4XUY"
FT TURN 145..147
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 150..157
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 163..165
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 169..174
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 177..189
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 193..200
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 208..222
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 229..232
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 240..243
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 244..251
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 257..266
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 271..282
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 287..293
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 303..305
FT /evidence="ECO:0007829|PDB:4XUY"
FT STRAND 308..310
FT /evidence="ECO:0007829|PDB:4XUY"
FT HELIX 318..325
FT /evidence="ECO:0007829|PDB:4XUY"
SQ SEQUENCE 327 AA; 35486 MW; B0769C723DD3CA09 CRC64;
MVQIKVAALA MLFASQVLSE PIEPRQASVS IDTKFKAHGK KYLGNIGDQY TLTKNSKTPA
IIKADFGALT PENSMKWDAT EPSRGQFSFS GSDYLVNFAQ SNNKLIRGHT LVWHSQLPSW
VQSITDKNTL IEVMKNHITT VMQHYKGKIY AWDVVNEIFN EDGSLRDSVF YKVIGEDYVR
IAFETARAAD PNAKLYINDY NLDSASYPKL TGMVSHVKKW IAAGIPIDGI GSQTHLSAGG
GAGISGALNA LAGAGTKEIA VTELDIAGAS STDYVEVVEA CLNQPKCIGI TVWGVADPDS
WRSSSTPLLF DSNYNPKPAY TAIANAL
