ID   CAPL_STAAU              Reviewed;         424 AA.
AC   P39861;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Protein CapL;
GN   Name=capL;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49951 / M / NCTC 10649;
RX   PubMed=7961465; DOI=10.1128/jb.176.22.7005-7016.1994;
RA   Lin W.S., Cunneen T., Lee C.Y.;
RT   "Sequence analysis and molecular characterization of genes required for the
RT   biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus.";
RL   J. Bacteriol. 176:7005-7016(1994).
CC   -!- FUNCTION: Required for the biosynthesis of type 1 capsular
CC       polysaccharide.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; U10927; AAA64651.1; -; Genomic_DNA.
DR   AlphaFoldDB; P39861; -.
DR   SMR; P39861; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Exopolysaccharide synthesis; NAD;
KW   Oxidoreductase.
FT   CHAIN           1..424
FT                   /note="Protein CapL"
FT                   /id="PRO_0000074072"
SQ   SEQUENCE   424 AA;  47184 MW;  4443C58B6C12F2E4 CRC64;
     MNRNIAVVGL GYVGLPVAVT FGNKHKVIGF DINESRIKEL KNNYDRTNEV TENKLKNTNI
     EYTSNAEDLK KADFIIIAVP TPIDKHNKPD LLPLLKASET VGKVITPDTI VVYESTVYPG
     ATEEECVPVL EKYSGLVCGK DFFVGYSPER INPGDKVHTF ETITKVVSGQ TLEVLEIVAD
     VYSSVVTAGV HKASSIKVAE AAKVIENTQR DVNIALMNEL AIIFDKLDID TNEVLKASGT
     KWNFLNFKPG LVGGHCIGVD PYYLTHKAQE VGHHPEVILA GRRINDNMAK YIASNVIKEL
     LKQGLEVQGA TVNVLGLTFK ENCPDLRNTK VIHIIEELKE YGLNVTVNDV EADKNEAKKF
     FGLDLIDTKE LKMVDVVLFA VPHKDYMENK KDYINLVKDC GIVFDIKGII NSDELNVSQR
     LWRL