CAPON_DROME
ID CAPON_DROME Reviewed; 698 AA.
AC Q8SXX4; Q9VT10; Q9VT12;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Capon-like protein;
GN ORFNames=CG42673;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12505997; DOI=10.1242/dev.00293;
RA Butler M.J., Jacobsen T.L., Cain D.M., Jarman M.G., Hubank M.,
RA Whittle J.R.S., Phillips R., Simcox A.;
RT "Discovery of genes with highly restricted expression patterns in the
RT Drosophila wing disc using DNA oligonucleotide microarrays.";
RL Development 130:659-670(2003).
CC -!- FUNCTION: Putative adapter protein. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8SXX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8SXX4-2; Sequence=VSP_012464;
CC -!- TISSUE SPECIFICITY: Expressed at higher level in wing imaginal disk.
CC {ECO:0000269|PubMed:12505997}.
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DR EMBL; AE014296; AAF50244.3; -; Genomic_DNA.
DR EMBL; AE014296; AAF50246.2; -; Genomic_DNA.
DR EMBL; AY075524; AAL68331.1; -; mRNA.
DR EMBL; AY129453; AAM76195.1; -; mRNA.
DR EMBL; BT001734; AAN71489.1; -; mRNA.
DR RefSeq; NP_729509.1; NM_168352.2. [Q8SXX4-1]
DR RefSeq; NP_729510.1; NM_168353.2. [Q8SXX4-2]
DR AlphaFoldDB; Q8SXX4; -.
DR SMR; Q8SXX4; -.
DR IntAct; Q8SXX4; 13.
DR STRING; 7227.FBpp0291850; -.
DR PaxDb; Q8SXX4; -.
DR PRIDE; Q8SXX4; -.
DR DNASU; 39111; -.
DR EnsemblMetazoa; FBtr0302709; FBpp0291849; FBgn0261555. [Q8SXX4-1]
DR EnsemblMetazoa; FBtr0302710; FBpp0291850; FBgn0261555. [Q8SXX4-2]
DR GeneID; 39111; -.
DR KEGG; dme:Dmel_CG42673; -.
DR UCSC; CG32048-RA; d. melanogaster. [Q8SXX4-1]
DR FlyBase; FBgn0261555; CG42673.
DR VEuPathDB; VectorBase:FBgn0261555; -.
DR eggNOG; KOG4815; Eukaryota.
DR GeneTree; ENSGT00940000169335; -.
DR HOGENOM; CLU_014963_0_0_1; -.
DR InParanoid; Q8SXX4; -.
DR PhylomeDB; Q8SXX4; -.
DR BioGRID-ORCS; 39111; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG42673; fly.
DR GenomeRNAi; 39111; -.
DR PRO; PR:Q8SXX4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0261555; Expressed in crop (Drosophila) and 40 other tissues.
DR ExpressionAtlas; Q8SXX4; baseline and differential.
DR Genevisible; Q8SXX4; DM.
DR GO; GO:0098978; C:glutamatergic synapse; ISS:FlyBase.
DR GO; GO:0050998; F:nitric-oxide synthase binding; IBA:GO_Central.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0098974; P:postsynaptic actin cytoskeleton organization; ISS:FlyBase.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR PROSITE; PS01179; PID; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..698
FT /note="Capon-like protein"
FT /id="PRO_0000089315"
FT DOMAIN 25..194
FT /note="PID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT REGION 191..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 265..327
FT /evidence="ECO:0000255"
FT COILED 379..484
FT /evidence="ECO:0000255"
FT COILED 554..583
FT /evidence="ECO:0000255"
FT COMPBIAS 197..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..146
FT /note="MPSTPYDLVQDDQDLRVPLHAEQAFFHGITFQAKFVGWEEVPRPNTRAEIVQ
FT AMRRIRYECKVQNLKKRKVTIHISVNGVRVVLKKRRRKKKNWTNDPEDIELLNHPIYRI
FT FYVSHDSSDLKIFSYIARDASTDTFKCSVFKSHKK -> MKHEKTLAMAAPHKQRHADS
FT SAHVVPRSPITKAFDFLPWTRSRSKVNMTKVQSQPAEQQASVSTVTPAEKSSEVHYHKN
FT IFRSGGGLIRDILVGDKNLQLKDKPPQSPVPSHKKKQKHLSRNKSLDIRELIGCVEREM
FT APATGGGPVSQPPRFIDDTYIDHKPKHILFNDDENTVYIIKKEQPVAKSSHKASNSTSN
FT AAQSNGDVLKARLKFKRLPGDHYEASPEALRRAHLLHQRSEQRHQLQRRKSLSDQQSSS
FT SLSSGGGGGGNANGSIMLERPKTDKPRKKLSFREPIIAGDQILPLILSEQRQARQRRRS
FT SPLERSRVGLAIADCDNLCNNRTKDAISCGCATSDPE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_012464"
SQ SEQUENCE 698 AA; 77280 MW; CAC802BA3457C976 CRC64;
MPSTPYDLVQ DDQDLRVPLH AEQAFFHGIT FQAKFVGWEE VPRPNTRAEI VQAMRRIRYE
CKVQNLKKRK VTIHISVNGV RVVLKKRRRK KKNWTNDPED IELLNHPIYR IFYVSHDSSD
LKIFSYIARD ASTDTFKCSV FKSHKKSQAM RIVRTVGQAF EVCHKFNLHK NSLEPNDERS
DISSSELLDV EQISEQQLSE DGERGGGDNE TPKKEHLAIT PDLNHTQPQR PNHLDIMPSH
SSLRKSNSLL CDVDDKSPGS PSSPRSEITQ LKDQLEAQAL QTRQALGQLM LVREQLISET
NARIEAQART QQLLQQNREL LEHLASLGAY NEQQTAGLTS ANIGMAPQQS QLQMLLQATS
NNNNLATINQ QISNLGSINQ QLTSLSHQLS GLNQQSQHLQ NLQQQQQQQQ QQQQQQTQAA
PTAATPPPAA GGSSPYPSMS ALQSISNQLQ QQQQQQQQDA LSKDLFQVNQ ELLNRLQALN
LNANPGQSQP TPSATAHNSF FYVNPLSCTP ATPNNNAGGA GGFNFLTSPA ATGTLTPSPL
GTMNRNSFAG SSSLNEDIRL SIEQNLNNLE EQLKAAVSNG NLAGLACGGS TSTRDTSRSS
STLDSPSSPR LRSSNNNISP GSSNGNQNHN NNSNSNSSSS RETRFNTVLL RVTDEAGHQR
KLSATPSFIT RSTSEKVPNR SQMMSQVQRT TWARHTTK
