XYNR_ECOLI
ID XYNR_ECOLI Reviewed; 252 AA.
AC P77300; Q2MCF0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=HTH-type transcriptional regulator XynR {ECO:0000305};
DE AltName: Full=Regulator of xylonate catabolism {ECO:0000303|PubMed:29087459};
GN Name=xynR {ECO:0000303|PubMed:29087459}; Synonyms=yagI;
GN OrderedLocusNames=b0272, JW0265;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, DNA-BINDING, ACTIVITY REGULATION, AND DEVELOPMENTAL STAGE.
RX PubMed=29087459; DOI=10.1093/femsle/fnx220;
RA Shimada T., Momiyama E., Yamanaka Y., Watanabe H., Yamamoto K.,
RA Ishihama A.;
RT "Regulatory role of XynR (YagI) in catabolism of xylonate in Escherichia
RT coli K-12.";
RL FEMS Microbiol. Lett. 364:0-0(2017).
CC -!- FUNCTION: Involved in regulation of xylonate catabolism. Represses the
CC expression of both yagA and yagEF operons. Binds mainly at a single
CC site within the spacer of the bidirectional transcription units yagA
CC and yagEF. {ECO:0000269|PubMed:29087459}.
CC -!- ACTIVITY REGULATION: Activity may be controlled by xylonate.
CC {ECO:0000269|PubMed:29087459}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the exponentially growing phase.
CC Level decreases down to an undetectable level during stationary phase.
CC {ECO:0000269|PubMed:29087459}.
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DR EMBL; U70214; AAB08693.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73375.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76056.1; -; Genomic_DNA.
DR PIR; H64752; H64752.
DR RefSeq; NP_414806.1; NC_000913.3.
DR RefSeq; WP_001121657.1; NZ_LN832404.1.
DR AlphaFoldDB; P77300; -.
DR SMR; P77300; -.
DR BioGRID; 4261498; 8.
DR IntAct; P77300; 5.
DR STRING; 511145.b0272; -.
DR jPOST; P77300; -.
DR PaxDb; P77300; -.
DR PRIDE; P77300; -.
DR EnsemblBacteria; AAC73375; AAC73375; b0272.
DR EnsemblBacteria; BAE76056; BAE76056; BAE76056.
DR GeneID; 945016; -.
DR KEGG; ecj:JW0265; -.
DR KEGG; eco:b0272; -.
DR PATRIC; fig|1411691.4.peg.2008; -.
DR EchoBASE; EB3133; -.
DR eggNOG; COG1414; Bacteria.
DR HOGENOM; CLU_062618_7_1_6; -.
DR InParanoid; P77300; -.
DR OMA; FGCVAAP; -.
DR PhylomeDB; P77300; -.
DR BioCyc; EcoCyc:G6144-MON; -.
DR PRO; PR:P77300; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:EcoCyc.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0044010; P:single-species biofilm formation; IMP:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..252
FT /note="HTH-type transcriptional regulator XynR"
FT /id="PRO_0000201769"
FT DOMAIN 4..66
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 81..250
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 25..45
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ SEQUENCE 252 AA; 27838 MW; 8FF297AE8FF2E435 CRC64;
MPIIQSVERA LQILDLFNEQ ATELKITDIS KLMGLSKSTL HSLLKTLQLH GYIDQNPENG
KYRLGMKLVE RGHFVVGSID IRQKAKGWLT ELSRRTGQTT HLGILDGREG VYIEKIEGKL
AAIAYSRIGR RLPVHATAIG KVLIAWLGEA ELNALLEGYQ YTTFTPATLA SREALMSALA
QTREQGYALD SEENEQGVRC VAVPVWNHES RVIAALSLST LTSRVDDAEL ANFREQLQQA
GLALSRALGY PA
