ID   X_BDV1                  Reviewed;          87 AA.
AC   P0DOF1; Q8JJK0; Q912Z9;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   02-JUN-2021, entry version 13.
DE   RecName: Full=X protein;
DE   AltName: Full=p10;
GN   Name=P/X;
OS   Borna disease virus 1 (BoDV-1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Bornaviridae; Orthobornavirus.
OX   NCBI_TaxID=1714621;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9352; Bradypodidae (three-fingered sloths).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=9850; Cervidae (deer).
OH   NCBI_TaxID=109474; Crocidura leucodon (Bicoloured white-toothed shrew) (Celebes shrew).
OH   NCBI_TaxID=9788; Equidae (horses).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=56798; Hexaprotodon liberiensis (Pygmy hippopotamus) (Choeropsis liberiensis).
OH   NCBI_TaxID=9844; Lama glama (Llama).
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
OH   NCBI_TaxID=8801; Struthio camelus (Common ostrich).
OH   NCBI_TaxID=9455; Varecia variegata (Black-and-white ruffed lemur) (Lemur variegatus).
OH   NCBI_TaxID=30538; Vicugna pacos (Alpaca) (Lama pacos).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate CRNP5, Isolate CRP3A, and Isolate CRP3B;
RX   PubMed=12163584; DOI=10.1128/jvi.76.17.8650-8658.2002;
RA   Nishino Y., Kobasa D., Rubin S.A., Pletnikov M.V., Carbone K.M.;
RT   "Enhanced neurovirulence of borna disease virus variants associated with
RT   nucleotide changes in the glycoprotein and L polymerase genes.";
RL   J. Virol. 76:8650-8658(2002).
CC   -!- FUNCTION: Plays an essential role in the inhibition of host apoptosis.
CC       Mediates host mitochondria-mediated apoptosis through interaction with
CC       the mitochondrial antiviral signaling protein/MAVS and thereby promotes
CC       viral persistence in host central nervous system. Within the host
CC       nucleus, regulates viral RNA synthesis and polymerase complex assembly.
CC       {ECO:0000250|UniProtKB:P0DOF0}.
CC   -!- SUBUNIT: Interacts with P and N proteins. These interactions presumably
CC       promote nuclear targeting of the X protein in infected cells. Interacts
CC       with host MAVS; this interaction inhibits MAVS-induced apoptosis.
CC       {ECO:0000250|UniProtKB:P0DOF0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Host mitochondrion
CC       {ECO:0000250|UniProtKB:P0DOF0}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P0DOF0}.
CC   -!- MISCELLANEOUS: The P/X gene has 2 overlapping open reading frames. One
CC       encodes the P protein and the other the X protein. The p24, X and p16
CC       proteins are produced by ribosomal leaky scanning.
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DR   EMBL; AY114161; AAM68135.1; -; Genomic_RNA.
DR   EMBL; AY114162; AAM68141.1; -; Genomic_RNA.
DR   EMBL; AY114163; AAM68147.1; -; Genomic_RNA.
DR   RefSeq; YP_009272535.1; NC_001607.1.
DR   GeneID; 28620039; -.
DR   KEGG; vg:28620039; -.
DR   Proteomes; UP000116075; Genome.
DR   Proteomes; UP000117149; Genome.
DR   Proteomes; UP000158638; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009485; BDV_P10.
DR   Pfam; PF06515; BDV_P10; 1.
PE   3: Inferred from homology;
KW   Host mitochondrion; Host nucleus; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus; Phosphoprotein.
FT   CHAIN           1..87
FT                   /note="X protein"
FT                   /id="PRO_0000439632"
FT   REGION          5..16
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:P0DOF0"
FT   REGION          18..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   87 AA;  9386 MW;  936743D28F9719FD CRC64;
     MSSDLRLTLL ELVRRLNGNA TIESGRLPGG RRRSPDTTTG TTGVTKTTEG PKECIDPTSR
     PAPEGPQEEP LHDLRPRPAN RKGAAVE