Y0038_DICDI
ID Y0038_DICDI Reviewed; 1192 AA.
AC Q54VU5;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0280131;
GN ORFNames=DDB_G0280131;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000035; EAL67292.1; -; Genomic_DNA.
DR RefSeq; XP_641260.1; XM_636168.1.
DR AlphaFoldDB; Q54VU5; -.
DR SMR; Q54VU5; -.
DR STRING; 44689.DDB0230038; -.
DR PaxDb; Q54VU5; -.
DR EnsemblProtists; EAL67292; EAL67292; DDB_G0280131.
DR GeneID; 8622392; -.
DR KEGG; ddi:DDB_G0280131; -.
DR dictyBase; DDB_G0280131; -.
DR eggNOG; ENOG502RSQH; Eukaryota.
DR HOGENOM; CLU_271739_0_0_1; -.
DR InParanoid; Q54VU5; -.
DR OMA; LWEMFAR; -.
DR PRO; PR:Q54VU5; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF00514; Arm; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00185; ARM; 3.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1192
FT /note="Probable inactive serine/threonine-protein kinase
FT DDB_G0280131"
FT /id="PRO_0000355171"
FT DOMAIN 521..783
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 23..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..234
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 527..535
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 549
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1192 AA; 132491 MW; C5B97018E847F4A6 CRC64;
MSELDDLLNE MLAESEAALN GQSTINLNNN NSNNNNNNNN NGNSATKISF QEQMPNGNGN
SSTTTTTAAQ QSATEKRKSR LSQHPSNLNE GGFDYLDTLL NDMSDESIRN SIKTDNSRIK
SLRLTSTFDL ESTLKDLEET FMKDSSIQNK RKPSSYLSKN LSPPSNPSNI ISNNNASTLP
LPPPPSQQDD VVIIAKLPPP VSISLPPPPT TEELPLPPPS TEELQLPPPP PTTTTADEQI
LTDSVKNGNP ILKRVSSERA IILTKEAIDA ADLLDEMIES FGGIPEPNGN NSLPKEIKTT
SIPTPIVTPS TTTSTNTTTA ATVNKLNASK SPNGTLTTRP AAKLGAPVDI QVSSPKAPTP
IPTLSSPSPS QSAAPQPAAP QPTPTSQPQP PTTTVSTPVS PTFKDSDQLL DDMISHFKES
NSNLLTSSSN LDPSAPKVVY TSQQFYPLSV EEQSLQSKVK VQLTPDEQVI QKILGNNDLD
DDITNKNNDN NSNGNNNNKE LIDEQNQIEQ QQSDKSWYIK AQPSDIIGSG NNGTTQRAGI
HKDKRIVMKQ WNFITSQATP MLFNEIEQLV AIKHPNILAL AGASFDNQTF TTFTEYITGS
NLDIVIKNLD EKNELQLILR LSEEIASAMS FLHSFNIVHR SLHPKNILLN SDLKIYIKDY
GFTSLKDETL KKKFMSFQLK NQLLHTQYLA PELFNVLSGS KGGYDTKVDV FSFGVLLWEM
FARDIKLSDL KSNTVNGYTH YLRPPLPNCP FTIEKLIKLC LSTDPSVRPT FTTILKILRQ
PLHTIQRFNK PTQQQQQQQQ QDQQQQQPEQ QLTSSTSSTS TQDSLVSQEQ VEEKIKNEMN
NLLNPNKRFN ESLDPEKRVK IEKIANVVKD LISQPTLLNL HRASQTIDQL CKNVENIEYL
LEADFVPLIF QLMDQPYDEI QLSCLKQFST LIEHNEEIMN LFRNLLGINI LMETLNSQKE
NILFITLRLL SQLSNGADRE ENREQILIKG GIPLLINLLS HQNELIRLQI LWCLTLLLES
NSVQVEFVKL GGVNQLLDMM VHSINSGFDL RVASALARVI SLKSVQDQIN LGHYRERVVK
KYLSLLGDTQ FEALRMLGLE AIACLVSNKD SQFILTASNI VDLLLSYLDP NSTSMAPQMT
ALKIILVLSV NPIHIPYLKS SNIIEPLQYL KSSPHPSIQK AVEKILMLVS SK
