ID   Y006_METJA              Reviewed;         378 AA.
AC   Q60314;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized oxidoreductase MJ0006;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MJ0006;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000250};
CC       Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-
CC       bis-MGD) cofactor per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB97987.1; -; Genomic_DNA.
DR   PIR; F64300; F64300.
DR   RefSeq; WP_010869499.1; NC_000909.1.
DR   AlphaFoldDB; Q60314; -.
DR   SMR; Q60314; -.
DR   STRING; 243232.MJ_0006; -.
DR   EnsemblBacteria; AAB97987; AAB97987; MJ_0006.
DR   GeneID; 1450845; -.
DR   KEGG; mja:MJ_0006; -.
DR   eggNOG; arCOG04862; Archaea.
DR   HOGENOM; CLU_039904_0_0_2; -.
DR   InParanoid; Q60314; -.
DR   OMA; GHCICNS; -.
DR   OrthoDB; 1029at2157; -.
DR   PhylomeDB; Q60314; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR   InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 2.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR   PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR   PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..378
FT                   /note="Uncharacterized oxidoreductase MJ0006"
FT                   /id="PRO_0000063231"
FT   DOMAIN          1..57
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         8
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         11
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         15
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         43
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
SQ   SEQUENCE   378 AA;  42051 MW;  E0C13060FF2609AA CRC64;
     MKVVHTICPG CSVGCGIDLI VKDDKVVGTY PYKRHPINEG KNCSNGKNSY KIIYHEKRLK
     KPLIKKNGKL VEATWDEALS FIAEKLKNYN ADDITFIASG KCTNEDNYAL KKLVDSLKAK
     IGHCICNSPK VNYAEVSTTI DDIENAKNII IIGDVFSEHA LIGRKVIKAK EKGSKVTIFN
     TEEKEILKLN ADEFVKVDSY LGVDLSNVDK NTIIIINAPV NVDEIIKTAK ENKAKVLPVA
     KHCNTVGATL IGIPALNKDE YFELLKNSKF LYIMGENPAL VDKDVLKNVE FLVVQDIIMT
     ETAEMADVVL PSTCWAEKDG TFINTDKRIQ KINKAVNPPG DAMDDWLIIK SLAEKLGSDL
     GFNSLEDIQQ DIHRNKLL