ID   Y011_CLOBH              Reviewed;         893 AA.
AC   A5HXQ7; A7FZT7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=UPF0182 protein CBO0011/CLC_0020 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=CBO0011, CLC_0020;
OS   Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=17519437; DOI=10.1101/gr.6282807;
RA   Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA   Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA   Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA   Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA   Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   White B., Whithead S., Parkhill J.;
RT   "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT   Hall A and comparative analysis of the clostridial genomes.";
RL   Genome Res. 17:1082-1092(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; CP000727; ABS38435.1; -; Genomic_DNA.
DR   EMBL; AM412317; CAL81565.1; -; Genomic_DNA.
DR   RefSeq; WP_011947903.1; NC_009698.1.
DR   RefSeq; YP_001252563.1; NC_009495.1.
DR   RefSeq; YP_001385973.1; NC_009698.1.
DR   AlphaFoldDB; A5HXQ7; -.
DR   SMR; A5HXQ7; -.
DR   GeneID; 5184266; -.
DR   KEGG; cbh:CLC_0020; -.
DR   KEGG; cbo:CBO0011; -.
DR   PATRIC; fig|413999.7.peg.11; -.
DR   HOGENOM; CLU_007733_0_0_9; -.
DR   OMA; HLRYPQD; -.
DR   PRO; PR:A5HXQ7; -.
DR   Proteomes; UP000001986; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..893
FT                   /note="UPF0182 protein CBO0011/CLC_0020"
FT                   /id="PRO_0000335541"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
SQ   SEQUENCE   893 AA;  104057 MW;  373E2697913CBAFB CRC64;
     MKNKKALFIP LFIIILFIAF FNKIINFIIN IKWFKEVNYL AVYFTKMRAI IILMIPIFII
     FFISIWMYYK SLIINKNKSV VDIGLNKNNY GKKLFFIFNF IVSIFLAYIF SSSYWYRILQ
     FNNSVDFNVK DPIFFKDVSF YIFKLPLFES LYKVIISLLL FLVITTFIAY FILEAKYKIQ
     SKKDINLKNI NHGIKSFAGK QLAIVSGLII LFISFGHLIK IWNLVYSSNG VSFGASYTDV
     HATLLFYKII VVITLISSIV TLLSIVKGKF KPVSICIGIT IFLIVSQNIA SFLVQNFIVK
     SNEKTLEQPY IKNNIDLTRK AFALDDIEIR DFDIKNDLQK QDITDNKASI DNIRINSFKP
     TLEFYNQVQI IRYYYTFNDI DIDRYNINGK YNQVFLAARE IDTDALNPNT WQNRHLIYTH
     GFGAVMNKVN SVTSEGQPDF VIKDIPPYNK TNIKLANPRI YFGEKTNDYV IVNTKINEFD
     YPKEDSNKTN KYNGHAGIKM SFINRLLFAI NKKDINFLLS KDIKKDSKII INRNIVERAK
     KIAPFLTYDS DPYMVIYNGK IYWIIDAYTT TNRYPYSEPY DSINYIRNSA KVVIDSVDGD
     INFYITDKKD PIVNNYAKIF KGLFKEEKDA PKEIREHFRY PKDLFSIQSK VLGKYHVKDP
     GVFYNGEDLW EVSKDQKHVE GETNTNDAPY IIMKLPDQNK EEMVLLNYFN VMKKDNMIAL
     FGARMDGEQY GKKILYKLPS DKTVYSPYLF KQKINQDTNI SKELSLWNRE GSKVQYGDTI
     ILPIKNSLLY IEPLYLRASG KNSIPEMKRV ILSYNDKLVL SSSIQEGIKE IFNSKDNKIN
     DKNEKDSTKT IDDSKLKKAQ EYYNKAIEAQ KNGDWTKYGE NINELGNILN SIK