Y0124_DICDI
ID Y0124_DICDI Reviewed; 1936 AA.
AC Q54XI9;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0278909;
GN ORFNames=DDB_G0278909;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
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DR EMBL; AAFI02000024; EAL68056.1; -; Genomic_DNA.
DR RefSeq; XP_647814.1; XM_642722.1.
DR AlphaFoldDB; Q54XI9; -.
DR SMR; Q54XI9; -.
DR STRING; 44689.DDB0230124; -.
DR PaxDb; Q54XI9; -.
DR EnsemblProtists; EAL68056; EAL68056; DDB_G0278909.
DR GeneID; 8621774; -.
DR KEGG; ddi:DDB_G0278909; -.
DR dictyBase; DDB_G0278909; -.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_235097_0_0_1; -.
DR InParanoid; Q54XI9; -.
DR OMA; HQFSETG; -.
DR PRO; PR:Q54XI9; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; SSF48371; 2.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome;
KW Repeat.
FT CHAIN 1..1936
FT /note="Probable inactive serine/threonine-protein kinase
FT DDB_G0278909"
FT /id="PRO_0000355172"
FT REPEAT 61..82
FT /note="LRR 1"
FT REPEAT 83..103
FT /note="LRR 2"
FT REPEAT 104..125
FT /note="LRR 3"
FT REPEAT 126..147
FT /note="LRR 4"
FT REPEAT 151..173
FT /note="LRR 5"
FT DOMAIN 191..230
FT /note="LRRCT"
FT REPEAT 325..368
FT /note="HEAT 1"
FT REPEAT 439..476
FT /note="HEAT 2"
FT REPEAT 574..614
FT /note="HEAT 3"
FT REPEAT 617..654
FT /note="HEAT 4"
FT DOMAIN 961..1241
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 1317..1356
FT /note="HEAT 5"
FT REPEAT 1512..1549
FT /note="HEAT 6"
FT REPEAT 1553..1590
FT /note="HEAT 7"
FT REPEAT 1598..1635
FT /note="HEAT 8"
FT REPEAT 1690..1728
FT /note="HEAT 9"
FT REPEAT 1739..1775
FT /note="HEAT 10"
FT REPEAT 1780..1817
FT /note="HEAT 11"
FT REPEAT 1821..1858
FT /note="HEAT 12"
FT REPEAT 1863..1900
FT /note="HEAT 13"
FT REGION 253..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..543
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 967..975
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 988
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1936 AA; 213056 MW; 167624207E29A94C CRC64;
MSLKGSLKLP AAPKDKVRNI TKFPVLVEGE VVTNYAQKDV RPIFQKLSYP VFIDLSEGIY
LLEKLNLSSN SLIEVTSLGH LNKLKRLILN RNNLIEYSVQ GLSSLVYLGL CNNRIDRITD
MSDCKKLINI DLSGNRLTCG DGFDHFSKLK SLKVLDLSSN SINCSLIDFQ KKILEPLKKS
KTLEYLSFEN NLIEKKYEEF RLFVINELPK LKYLNWVLIS KDERTKASKL DSEGFFSKQL
SILSVTPVVH NNNNPNNTVT SAQSSPSLSS VSTPIPTPLN TSSNNIGGGG SGTTTSVSVG
SSPTIRGMPS SPNSRSTSFI QRKPSVGANM MPKLNSSLNR STDFLGKERE NHQSTSPSSS
SLSISSSSQN NNSNHHHHHP KSIDETPEVL SPFDILQSKV NAENCLSSSQ QDLIVNHNNL
TTASQILQEI KPTKELTKQE TEDYIDILLN ELQPNNTDFP TFASVIDQKV YLDLLYRAII
EDAIPEELIE ECNKSTTTAA TAAAVVDFVT PQLTSLSSSS SSSSTTPPQP QLPPPPPQQQ
QLDLSLPLPP VNIINMPMDD DELISVPTDE SELPVVSTIV PSLVKESSRE SLLVTTIDNS
TLSTTPPLSS TTPPSPSPKL PTLEETIESV VTAKPSSTTT TATQTNKVSG GSAKEIWTKI
DQNTATTPST PSKNLPKRLP SQSNLINNNN NNNVINVPPP TQSILKPVVG GGSGSTPSSP
QMKPMAKPIA KIPAVSTTTN TTPTSTPGSP SKPIMKPVIK KVPAISLKQD QPPIVSPPQP
QPQPPIVQQK QQQQQQQQQQ QQPQQHFKSE IDKALADIDS WGVIPTAPQA EIKKPIIPQE
LLSNIQKVES PTEMVENATS KLDEMIMEYH NTSPTSSPTN TRKSITPVQQ QQPIQQPIQQ
PIQQPIQQPI QQPIQQQQQP PIQQIDQVQR MINNETNRIG SMMILGQNIS LPNWIVPHDQ
IQVGSRLGLG SFGDCYTGNA FSIPTILKKL RTQRFTDQFL GQFKNEVMQI RELQHENLVP
VSGCCLDNNI YIVHPYYDAS NLQTLLFEQS HNNNNNNNNN NNNNNNNNNN NNNNNNHTII
SNEFIHRVSL GISKAMTYLH SHDVVHRALK LNNILIDRVS GNVLVRDYGF NFVKDGIFRT
GQQSSPYLAP ELFNSNCNQY DTNSDQFGFA MILLQLFTRS PLFQDIHVSR ITDTILNGVR
PEIPDNVPSV FSRLIKACWS ADSSARPSFL TISKILSQPF QRIFALSPST TITKPIVSTG
NTTIDSSSSS SGSGSSSVVG SVNSTTIPPV NNSNTGSTGS TSATVKHQFS ETGELNRKMI
LVLERIVSML STAAASASTS TISTDSIDSI KRALKALENL SSPENHSSMV GIGLMRSLCF
IGTIHLAEID EQLLRVIYSL STNEQLSNEF ILAGGFTPLS QWVSSSSSSS TSANISLLAI
KLLTVLADEQ HLHHVRLTGI LSSLTQQFVN YTSNNQNGGG GSGGGVINET IILQSVGAMS
RILLNQDNQN QFIEEGGVSS LLKMLLNSGN SLSMRALLAL CCLISNQNCK SQLHNAGIIP
KLMELLSSPQ KLLRLHSLKV IETMSKDIEF RKLLIQDNCL SLLVNLLLNS YNGTNTGIGN
NTTGNNNDSQ ESICSILSCI GSLLKNQIAL ESFYQSNGVD VLIKLIGYNQ QIEILESLFP
VYCLLINHEQ SRLKLVPTIN QLVEILSNST LKESIIISIL KCLTLFSSHS SCIEFIEQSM
SVSIVSTLLI RNENNYEIKI HSLRFVSSLA KVNNKLAVNI HMMGILQTLV NNLYDKNSMI
KDEAISTISW LVSSQECRSI FLQKNVLPML FDFLSTRNVD IMERLIWAIS FFALDDSAQS
LMRDNQQCIQ FIVNCLDRHE EVFKTLSIKT ILILSQKQIN HQALKRVGVD FQLQVLSSSS
NRSIQLASKK ILSLLS
