CAPPA_HALS3
ID CAPPA_HALS3 Reviewed; 492 AA.
AC B0R7F9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPC {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_01904};
DE EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01904};
GN Name=ppcA {ECO:0000255|HAMAP-Rule:MF_01904}; OrderedLocusNames=OE_4169F;
OS Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=478009;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
CC -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon
CC dicarboxylic acid source for the tricarboxylic acid cycle.
CC {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- SIMILARITY: Belongs to the PEPCase type 2 family. {ECO:0000255|HAMAP-
CC Rule:MF_01904}.
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DR EMBL; AM774415; CAP14678.1; -; Genomic_DNA.
DR RefSeq; WP_010903679.1; NC_010364.1.
DR AlphaFoldDB; B0R7F9; -.
DR SMR; B0R7F9; -.
DR EnsemblBacteria; CAP14678; CAP14678; OE_4169F.
DR GeneID; 5954011; -.
DR GeneID; 62885408; -.
DR KEGG; hsl:OE_4169F; -.
DR HOGENOM; CLU_517433_0_0_2; -.
DR OMA; QSAFRYD; -.
DR PhylomeDB; B0R7F9; -.
DR Proteomes; UP000001321; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR HAMAP; MF_01904; PEPcase_type2; 1.
DR InterPro; IPR007566; PEP_COase_arc-type.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR Pfam; PF14010; PEPcase_2; 1.
DR PIRSF; PIRSF006677; UCP006677; 1.
DR SUPFAM; SSF51621; SSF51621; 1.
DR TIGRFAMs; TIGR02751; PEPCase_arch; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation; Lyase; Magnesium.
FT CHAIN 1..492
FT /note="Phosphoenolpyruvate carboxylase"
FT /id="PRO_1000188767"
SQ SEQUENCE 492 AA; 54179 MW; 12FBE025EF21C6D2 CRC64;
MVDVPRLMST QHPDNATLPF FTAGDVIEGE DEIQEAYYVY SHLGCDEQMW DFEGKEGDEY
AVKKLLSRYD EFFADHQLGT DVRLTVRGPN PDVEGSEAKI LLEILESIPR SFDAARRFAG
EYGLETTAPI FEVIVPMVTD ADQLNAVHEY YERFVTGKAD EAVWDGRTVE EWVGEFDPAS
ITVIPLIEER EAMLAADDIV REYATAHDQD AVRVFLARSD PALNYGCLAA DLINKVALQR
LYEMSEATGV DVHPILGAGS APFRGNLTPE RAAATADAYS EVETFTVQSA FKYDYPVETV
RDGVATLRDA DLGAPPFPID EARALAVIDR TADAYADQVD AIAGTVNRLS SYVPDRRARK
LHVGLFGYAR EVGENALPRA IGYTASLYAV GCPPTLLGAH ALTDDDAAFV REAFPAYFDH
LADAARYFNP RCTDVLDLDD DTLAAAVERV DVTPNSEHRA ATDDAIDALQ RGDDDALRSA
IRRGARERQF LG
