Y0170_DICDI
ID Y0170_DICDI Reviewed; 1578 AA.
AC Q55C84;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Bromodomain-containing protein DDB_G0270170;
GN ORFNames=DDB_G0270170;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
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DR EMBL; AAFI02000005; EAL72435.1; -; Genomic_DNA.
DR RefSeq; XP_646597.1; XM_641505.1.
DR AlphaFoldDB; Q55C84; -.
DR SMR; Q55C84; -.
DR STRING; 44689.DDB0220693; -.
DR PaxDb; Q55C84; -.
DR EnsemblProtists; EAL72435; EAL72435; DDB_G0270170.
DR GeneID; 8617568; -.
DR KEGG; ddi:DDB_G0270170; -.
DR dictyBase; DDB_G0270170; -.
DR eggNOG; KOG1474; Eukaryota.
DR HOGENOM; CLU_245222_0_0_1; -.
DR InParanoid; Q55C84; -.
DR OMA; MSFQYQM; -.
DR PRO; PR:Q55C84; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain; Coiled coil; Reference proteome.
FT CHAIN 1..1578
FT /note="Bromodomain-containing protein DDB_G0270170"
FT /id="PRO_0000367482"
FT DOMAIN 752..824
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 957..1039
FT /note="NET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00857"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1184..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 479..506
FT /evidence="ECO:0000255"
FT COILED 851..903
FT /evidence="ECO:0000255"
FT COILED 1113..1150
FT /evidence="ECO:0000255"
FT COILED 1280..1308
FT /evidence="ECO:0000255"
FT COILED 1462..1544
FT /evidence="ECO:0000255"
FT COMPBIAS 16..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..652
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1578 AA; 173483 MW; CFD5E0C392B62137 CRC64;
MSLEQQDETV VEEETKTSFE TNNSTANNTN NNTDNTYKEE ILKSTESITR NDDKVDPTSA
TALEKDIINN GEYSGSSSSS GNNNINGSNN IKNIVIEKVE QLERVVVNNN NGDENNKDIH
DSSNNTEDID ISKSHIIKYD KDEMSTISTI HYSDDESSKE KQDNINSNNN NNKNKNEQII
NSENILDTPM TEASDQTTPS DTPPTLTNNT SSTTTTTTTN NTTTAATTTT NSRRKRNSLS
TPSSEMDPVL DSTSENNTTR KTRGSRNSKK EPEELLLTPE QAKELSNKSK KWIYVPIIEA
EAKKEEVLPA KRDRKQVFNE NIFSSSRKST TKGGEKKNDT ASTTNTPIIT AQQNTTPLSP
TQTTTTTTTP TTTTAQQNTP AQTESKPPTT ISINIKGSKS PKTTGGKQQK PTPPSPVVIS
QPVVPSTPVV ATTKKTNSRS KRSTANNNSE TTQTPEVVIS APTTTTAAIT TPINITPSSD
SATIQQLQQS ISMLEDKIRL ISSNNKVATE ILNNTITTTT TTAATSAIKD EEIIENTELQ
TTFTKSSTLA PPSSERKYSN LYSDDEDDTE MVDVSVSIPI PIPIPTPTQT TTKKTTLSKK
RKSNTSTIIP TTTIQQEQGQ EQGQQQPPQQ QQPPQQQQPP QQQQPPQQQP PQQSTSPSKT
QQENTSSTTT TTTTTTTTTN TEDTTTVIDK KPKKKPRHSA PLIPQIKPRL PLNGGSSERA
QRSSRGRMGK AMRDVVLTPV FKRCLDLLEE LFEHQHSPPF LVAVDPYALG ILDYFDVIKH
PMDLGTIKAS LIGGGYDTID KFAEDCRLVF SNAKTYNPST NPVHIMAQSL EDVFEKGFPK
VLIEPPSPPP KNVDQEKIEK LSNDLKNVTK ELEKFKKDDS NSINNNNNNN NNYNNNNNNN
NNNSSSSSSR SSSRKSHSSG SSSSHRSGSS RSSRGSSSSS SSSSSSSSSS SSSSSSSSSN
NKKYPKVTTE EKTKLGAEIT QLPVDLLPSI LQIIHNTNSL PEQKPGSEVV IDLMKFDDDI
LRRLSKFVEQ YKNGEIPQHA LPLSAPSSTH SSHSSSHDSS SNIREIEKLQ KQLDRLGKGQ
QNSSSSSSSS SHSKRISKPI SKARGRKVIS TSSSNLNNSS NNINNNNNNI NNYNNNNNYN
NNNNNNLNNN NNNNINSNLN NNLNNNNNKD DIVIDGFKKE NFSSIPEKDV ETDISESSDS
ESDSESGSSD SSSSYSDSDF SDSDNDRRRN YNNSYNNNNN NNNNNNSSNN FNNQNNSYNN
SNNNNNNNSS NNNNNNNNNN SNNNNSNNNN NNVNNNNNNH NNNNHNNNIN NNNNNINNNT
TQPSPSQQST SLTNEPIKPP TILQTVKKPA LPVTGSVASW SFDPTNNKES SSSSSTSSTS
STSNTTLTPI IQQSSLTHAS SPISSSTFVS FSSSSSTPPT NNLSPPSPGL PNSPSINSPS
SPSANNNNTD SAWNHFKAKN ITLKQKEKER VLQEEVLRKE REEKEEELKK EEEKKRIEME
EIKRLAKEKE EREAEETRKQ IESERAAARE AREKEKLNNS KGNMSFQYQM DVMASFEDNI
DSSGSLLNLQ LKPIEDPL
