Y018_MYCGE
ID Y018_MYCGE Reviewed; 1031 AA.
AC P47264; P47262; P47263; Q49209; Q49302;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Uncharacterized ATP-dependent helicase MG018;
DE EC=3.6.4.-;
GN OrderedLocusNames=MG018;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP SEQUENCE REVISION.
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 640-740 AND 802-902.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
RN [4]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT "Essential genes of a minimal bacterium.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC -!- DISRUPTION PHENOTYPE: Not essential, it can be deleted.
CC {ECO:0000269|PubMed:16407165}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
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DR EMBL; L43967; AAC71234.2; -; Genomic_DNA.
DR EMBL; U02179; AAD12465.1; -; Genomic_DNA.
DR EMBL; U01757; AAD10571.1; -; Genomic_DNA.
DR PIR; G64201; G64201.
DR PIR; H64201; H64201.
DR PIR; T09676; T09676.
DR RefSeq; WP_010869292.1; NC_000908.2.
DR AlphaFoldDB; P47264; -.
DR SMR; P47264; -.
DR STRING; 243273.MG_018; -.
DR PRIDE; P47264; -.
DR EnsemblBacteria; AAC71234; AAC71234; MG_018.
DR KEGG; mge:MG_018; -.
DR eggNOG; COG0553; Bacteria.
DR HOGENOM; CLU_000315_21_1_14; -.
DR OMA; VYRIIAK; -.
DR OrthoDB; 325071at2; -.
DR BioCyc; MGEN243273:G1GJ2-18-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.10810; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR007527; Znf_SWIM.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF04434; SWIM; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Metal-binding; Nucleotide-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1031
FT /note="Uncharacterized ATP-dependent helicase MG018"
FT /id="PRO_0000074380"
FT DOMAIN 590..751
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 868..1022
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT ZN_FING 50..85
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT MOTIF 702..705
FT /note="DEAQ box"
FT BINDING 603..610
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT CONFLICT 893
FT /note="D -> S (in Ref. 3; AAD10571)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1031 AA; 119737 MW; DD83F049B64B3A39 CRC64;
MTVAEIKKLA LNNQVFNEAK ALLEKGNVIF PKKFLKRKKI IIEVLDGKVF KVQINLKTAA
AHLDCSCSND KQNCVHIIAA LLKYNDLKNQ DNKEFDLNKA DKLECKEVEI LIENVSLAIV
NGSWKLKIGF VINIDKVQTN TTALRFYCCD NKDVYFLHTE DEQLFRIALD KFNSVERQTL
LIFDQLNKTK QMQYENNSLL FNLDQFLSLV KEVKKPSLFL LNEDKTDNIL FLRSQHKING
LSHVCGFLNN KVFDFVSYNE KTKQIVLRLA YLNKFTDFKF PYNINIYKLA FGETLFFHFL
IHLKMNGFKN IFFQSDVVIV KESEYLPKMF LTIEFNTQKN KFITDAFFKY KNKNSNTLTT
VYPHRYYLAQ KTNTSNFNRL LFYEQALQRF YEELFQIDYL RRFENIPIKD KNQIALFKTV
FDDYKTIDLA ELKLTSNLLN YKQLHFSISD IKALKIEDRQ LKIEFKAGGI DLKLIKSVLS
NYYKGNAICI GEDGWYDLND ENAKALISFW SQIDLRNATC DANNNLLLAK YHLFEVVDTI
SKYTDVTNLL DEKTALQLKI ASENQFHLSL DNNQINNLRK YQKEGVKWIR ALEDNQFGGI
LADEMGLGKT AQVIFAMLDS YQSTKSLLPS LIIVPASLLL NWKSEFQKFA PHVKIVTANG
NFKERSQVYE SLKNQILLMS FNVLRSDIKW ISQKKFHYVV IDEAQGIKNE NSTVTKAAKK
IKGNFCLALT GTPIENRLLD LWSCFDFVLP NFLGNKKQFS DQFEKEKNDE SFQKLMKKTS
PFILRRTKNK VLKELPKKII TDIYVELSEE HQKLYDKQKT DGLKEIKESD AKNALNILSL
ILKLRHICSL VKDNDVNDFE DNSKANAALN IIYEALENKR KVILFTQFLD VIDCFKQTLK
NQKIDHLVFD GRKTVKNRNT IIQKFNSAKE PCVMLASLKA GGVGINLTAA EVVIHFDVWW
NSAVENQATD RAHRIGQSKT VQVYRIIAKN TIEERVCQVQ NQKQELVKKT LVEDVNFFKS
LSHEELLKLF E
